The Research Of Alkynes Cyclization Reaction Catalyzed By Silver To Construct Substituted Indoles

The transition metal-catalyzed alkyne cyclization reaction refers to the process of building a new C-C or C-heterocycle on an alkyne compound.When a carbocyclic ring is formed,the C-C bond is usually used to synthesize a polycarbonate ring to form a heterocyclic ring,and the construction of C-heterobond to form a heterocyclic compound.Since cyclized compounds can be seen everywhere in life and many of them are very important compounds,the study of cyclization methods is a very important research content in the field of chemistry.This research mainly foucus on cyclization of alkynes under the catalysis of transition metals.Because of the?-electron system,alkynes are highly reactive compounds.Under the catalysis of transition metals,alkynes will be activated and undergo ring formations to afford aromatization products.Construction of complex structures from simple alkynes is a long-secked method for synthesizing aromatic compounds,especially indole compounds.Since the indole structure is a priviling in natural products and drug molecules,the use of readily available catalysts to synthesize indole compounds under mild conditions is a very important research direction.We designed a series of azide-ynes,whose exposure to the catalysis of transition metals generated various indoles,providing effective and convenient method for the synthesis of some complex aromatic compounds.The main achievements of this thesis are as follows:Under silver catalysis,4-(2-azidophenyl)-4-methoxy-1-phenylbut-2-yn-1-one was converted to silver carbene intermediate,then underwent a ring formation to generate indole heterocycles.A method of efficient synthesis of indole heterocyclic compounds is provided.