Fluorescent Probes And Self-Assembly Based On Organic Small Molecules

Organic small molecule fluorescent probes have been used in chemistry,biology,clinical diagnosis and drug discovery due to their advantages of high sensitivity,high selectivity,low cytotoxicity,non-invasive damage to biological samples and good cell permeability.Supramolecular self-assembly refers to a process in which one or more molecules combine spontaneously by virtue of weak interactions between molecules to form highly ordered molecular aggregates with certain functions and structures.It has become one of the main means to construct new structures and new functional materials.In this paper,new coumarin-based fluorescent dyes C-1,C-2 and C-3 and binaphthol derivatives Binoal B were designed and synthesized.Among them,C-1 and C-2 were used to design a new fluorescent probe,and Binoal B and C-3 were used to construct a new artificial light-harvesting systems.C-1 was designed and synthesized as a fluorescent probe for hydrazine detection.C-1 was synthesized in one step reaction,and had good water solubility.The fluorescence was significantly enhanced after reacting with hydrazine.Spectral properties studies showed that the probe had high sensitivity and good selectivity,which could quantitatively detect over wide concentration range(0-200 μM),and the detection limit was as low as 1.89 ppb.Probe-coated filter papers were confirmed to detect gaseous hydrazine and hydrazine in actual water environment successfully.In addition,C-1 has been confirmed to detect hydrazine in living MCF-7 cells.Binoal B was designed and synthesized to form spherical nanoparticles by selfassembly in aqueous solution with SC4 AD under the synergistic action of electrostatic and hydrophobic.The nanoparticle had good fluorescence emission,which maked it an ideal energy donor in the aqueous solution.NiR and C-3 were selected as energy receptors to construct two novel artificial light-harvesting systems successfully.Both systems showed high energy transfer efficiency and antenna efficiency,which provided a new idea for designing artificial light-harvesting systems.