Construction Of A ROS-responsive Supramolecular Nanophotothermal Theranostic System With COX-2 As A Tumor Target

At present,malignancy is still a common disease and multimorbidity that seriously threatens human health,and is one of the most urgent public health problems.At present,the traditional cancer treatment methods mainly include surgical treatment,drug chemotherapy and radiation therapy,but surgical treatment often leads to tumor recurrence or metastasis due to incomplete surgical resection,drug chemotherapy is prone to drug resistance,radiation therapy brings great pain to patients,so photothermal therapy(PTT)because of its precision,controllability,high the inherent advantages of effectiveness,short treatment duration and rapid recovery have gradually improved the limitations of these treatments.Both traditional small molecule and macromolecular drugs in photothermal therapeutic agents have certain degrees of limitations,while supramolecular nanomedicines utilizing supramolecular design can improve the accuracy and effectiveness of drugs,non-ionic heptamethine(Cy7)dyes can self assemble into nanostructures via supramolecular,with unique photothermal and photoacoustic properties.In addition,the complexity and heterogeneity of tumors have prompted increasing interest in targeted therapy and stimuli responsive drug release,which can prompt drugs at the tumor site to fully exert their efficacy,and the main goal of targeted therapy is to more accurately fight cancer cells while reducing potential side effects.Despite the EPR targeting property of Cy7 based supramolecular Nanodiscs,only Its targeting efficiency is low by passive targeting,so here we introduce indomethacin and ROS stimuli responsive linkage bonds that can serve as targeting ligands to design supramolecular nanophotothermal agents.This newly developed supramolecular nanotheranostic system has unique properties:(1)can be self-assembled into nanodisc structures via supramolecules;(2)stimuli responsive drug release with high levels of reactive oxygen species(ROS)in the pathological microenvironment of tumors;(3)excellent tumor targeting performance;(4)photothermal effect significantly inhibits tumor growth without side effects;(5)longer retention ability of tumor tissue.