Studies On Copper-Catalyzed 1,2-Addition Of Conjugated 1-Substituted Terminal Dienes

Conjugated terminal dienes,as one of the important raw materials for organic synthesis,could be used to synthesize drugs and material isomers by controlling the regioselectivity and diastereoselectivity of the reaction.In addition,the obtained products are widely existed in bioactive compounds and natural products.Therefore,many well-known research groups have devoted themselves into studying the functionalization of conjugated terminal dienes and they already obtained some important achievements,especially in 3,4-addition and 1,4-addition.However,there are rare reports on 1,2-addition of conjugated terminal dienes.In this work,copper-catalyzed 1,2-addition of conjugated 1-substituted terminal dienes was disclosed.The addition of conjugated diene and aldehydes was realized under mild conditions,meanwhile,the 1,2-addition was obtained with high regioselectivity and high diastereoselectivity.In this transformation,the cheap copper salt was used as the catalyst,the environmentally friendly water was used as the hydrogen atom which reflected the green transformation of chemical reaction.In addition,this synthetic method provided the terminal alkenyl group containing product with different substrate scopes,a practical building block in organic synthesis,which provided a variety of possibilities for the subsequent transformation of products and laid a foundation for the synthesis of the corresponding complex structure.