Preparation Of Antibacterial/Hydrophilic Thermoplastic Polyurethane Material

Thermoplastic polyurethane(TPU)can meet the requirements of catheters to the greatest extent,and is used in many fields,such as tracheal intubation and indwelling needles.However,as an invasive instrument,once it causes infection,the consequences were so critical that it’s essential to improve the antibacterial properties of catheter materials.Based on this point,this subject endows TPU with antibacterial or hydrophilic properties respectively by blending antibacterial agents and preparing hydrophilic coatings.The quaternized chitosan(QCS)prepared with chitosan(CS)as the main raw material meets the requirements of antibacterial and processing,so it is blended with TPU to achieve antibacterial modification.Through a series of characterization,the following results can be obtained.When the amount of QCS reached 3%,the surface potential of the material was positive,which provided the possibility of antibacterial.Further exploration found that when the addition amount of QCS was 3%,the material could resist more than 99.99%S.aureus,and when the addition amount of antibacterial agent QCS was 4%,the material could kill more than 99.99%E.coli.When the addition of QCS reached 5%,the material can resist more than 99.99%of S.aureus and E.coli,and maintain its high antibacterial performance for more than three days,showing outstanding antibacterial activity against S.aureus under in vitro hydrodynamic conditions.In addition,QCS-TPU is a hydrophilic material with low hemolysis rate and cytotoxicity,which can be used for antibacterial modification of biomedical equipment and design and development of biocompatible materials.3-(2-Methacryloyloxyethyl trimethylamine)propanesulfonate(DMAPS)and poly(ethylene glycol)methacrylate(PEGMA)were chosen as hydrophilic components to improve the hydrophilicity of TPU by surface grafting.The reaction results were as follows.The water contact angle of the grafted DMAPS group was 8°,and the grafted PEGMA group was 10°.Neither of the two materials had cytotoxicity and hemolysis would not occur.However,further evaluation showed that the materials grafted with DMAPS had better hydrophilicity,long-acting hydrophilic property,smoother surface and more uniform grafting.The PEGMA-grafted materials had better anti-bacterial adhesion performance under the flow condition.Both of them can be used as high-quality hydrophilic anti-adhesion biological materials.This study presents a safe and nontoxic scheme for antibacterial and hydrophilic modification of thermoplastic polyurethane materials,which provides new strategies for development of antibacterial materials.