Design,Synthesis And Properties Of Iron-containing Nanomaterials Based On Metal-Organic Framework

Nano Metal-Organic Frameworks(NMOFs)are a class of inorganic-organic hybrid porous materials obtained by self-assembly of metal ions or ion clusters and organic bridging ligands.In recent years,this type of nano metal-organic frameworks with large specific surface area,adjustable pore size,diverse structure and different functions has shown excellent performance and broad prospects in the loading of chemotherapy drugs,photosensitizers and other therapeutic reagents.Dysregulation of cell growth and development can lead to the formation of malignant tumors.Malignant tumor is a public health threat worldwide,killing millions of people each year.Currently,the commonly used cancer treatment methods have certain defects and limitations,so it is urgent to explore effective and safe treatment methods.Photodynamic therapy(PDT)has been developed for more than 100 years as a non-invasive treatment.PDT remove solid tumors by transferring photon energy to photosensitizer and altering singlet oxygen(¹O₂)levels.Chemodynamic therapy can specifically apply the tumor microenvironment to induce tumor cell destruction by amplifying intracellular oxidative stress,or can increase the sensitivity of tumor cells to other antitumor therapies at the same time.Compared with traditional treatment,chemodynamic therapy and photodynamic therapy have obvious advantages of less invasion and higher selectivity.In this thesis,based on the metal-organic frameworks nano-platform,combined with the catalytic performance of iron-containing nanomaterials,two iron-containing nanomaterials with photodynamic therapeutic properties and chemical kinetic functions were designed and synthesized,respectively,and the corresponding performance studies were carried out.The specific content is as follows:(1)Design and synthesis of iron-containing nanomaterial FBNP-1 for photodynamic therapyIn the work of this chapter,considering that the hypoxia of tumor cells will seriously hinder the generation of singlet oxygen during photodynamic therapy,we first realized the improvement of the catalytic performance of iron oxyhydroxide by loading iron oxyhydroxide on ZrMOF,giving NMOF the ability to generate oxygen using hydrogen peroxide(H₂O₂),and then using the porosity of NMOF to load the photosensitizer indocyanine green to make the material has the ability to generate ¹O₂under the excitation of near-infrared light at the same time,and finally obtain the iron-containing nanomaterial FBNP-1.The experimental results show that in the presence of H₂O₂,the synthesized material FBNP-1 can generate oxygen,which can be further utilized by the photosensitizer and converted into active oxygen.At the same time,we found that porous metal-organic frameworks materials can effectively enhance the catalytic performance of iron oxyhydroxide.The composite material should be used for photodynamic therapy of hypoxic tumors.(2)Design and synthesis of iron-containing nanomaterial FBNP-2 for chemodynamic therapyIn the work of this chapter,base on the fact that Fe²⁺ion has excellent Fenton properties and can be used for excellent chemodynamic therapy,firstly,ZrMOF with uncoordinatedcarboxylgroupwassynthesizedbyusing1,2,4,5-benzenetetracarboxylic acid as the bridging ligand and Zr⁴⁺as the metal notes.The uncoordinated carboxyl functional group on the pore wall of ZrMOF was successfully used to load Fe²⁺.Then,the effective loading of chemotherapy drugs doxorubicin was realized through the porosity of NMOF to obtain an iron-containing nanomaterial FBNP-2.The results of chemical and cell experiments show that FBNP-2 can use loaded Fe²⁺to achieve Fenton reaction,react with H₂O₂to generate cytotoxic·OH,and cooperate with doxorubicin to achieve tumor cell killing.