Study Of The Electrochemical Sensor For Furaltadone

Furaltadone is one of the nitrofurans,and it is widely used in animals and aquatic products in the prevention and treatment of diseases.Furaltadone has the advantages of low cost and high efficiency,but the abuse of antibiotics can cause the problems of high residual and high side effects.Human consume animals containing antibiotics for long-term,it may influence the health of human.Thus,it is necessary to find a simple and rapid method for the detection of furaltadone.In this paper,the electrochemical sensor of poly（p-aminobenzenesulfonic acid）was developed for the determination of furaltadone.The main research work of this paper is as follows:（1）Poly（p-aminobenzene sulfonic acid）modified graphite electrode（PABSA/GE）was prepared by electropolymerization.The PABSA film was characterized by cyclic voltammetry,AC impedance method and chronocharging method.The results show that PABSA film has electrical activity.And it occurrs 2 electrons and 2 protons electrode reactions.On the basis of the results above,the electrochemical response of furaltadone（FTD）at PABSA/GE was studied.It found that the reaction of FTD at the modified electrode is mainly controlled by adsorption.It undergone two-step 2 electrons transfer of the electrochemical reduction reaction and one step 2 electrons transfer oxidation reaction.The reduction peak current of FTD is 4 times higher than that of the bare graphite electrode,which indicate that PABSA/GE has a catalytic effect on the electrochemical reduction of FTD.The results show that the electrocatalytic activity of PABSA/GE to FTD may be due to the increase of effective electrode area and the forming of the hydrogen bonding between the two components,which leads to the adsorption of FTD on the electrode surface.（2）The method of differential pulse voltammetry for the determination of FTD was established by PABSA/GE,and test conditions was optimized.The reduction peak potential of FTD was-0.230 V in the phosphate buffer solution（p H 2.00）.The current and concentration of FTD has a good linear relationship in the range of 1.00×10^-8～1.00×10^-6mol/L and 2.00×10^-6～9.00×10^-6mol/L with a detection limit of 1.00×10^-8mol/L.And the method was successfully applied in the analysis and detection of FTD in fish pond.（3）The screening of electrode modifier is a very cumbersome work.in research of chemical modified electrode.In this paper,p-aminobenzenesulfonic acid（SA）,o-aminophenol（OAP）and o-phenylenediamine（OPD）were used as potential electrode modifier.FTD as the object to be catalyzed,the application of UV-Vis spectrophotometry in screening electrode modifiers was studied.The electrode modifier is screened according to the changes of absorbed curves before and after the mixture of the two compents.It found that the absorption curves of SA and FTD both change after the mixture of the two components,meanwhile,PABSA/GE showed good electrocatalysis to FTD.While,the absorption curves of OAP and FTD both change slightly after the mixture of the two components.And both the absorption curves of OPD and FTD almost unchanged after the mixture of the two components.The modified electrode prepared with OAP or OPD as modifier does not show good electrocatalysis to FTD.The results indicate that UV-visible spectrophotometry has some reference value in the screening of electrode modifiers.