Lubrication And Dynamic Controlled Drug Release Properties Of Tween 85/Tween 80/H₂O Composite Lamellar Liquid Crystals

Friction caused by degeneration of articular cartilage often leads to joint inflammation Searching for suitable lubricating media to reduce frictional wear and inflammation has become an urgent problem.The lyotropic liquid crystals are a kind of substance between solid and liquid,with both the fluidity of liquid and the ordered structure of solid.The lamellar liquid crystals have similar lamellar structure to biological bilayers and have excellent lubricating properties.Nanomaterials have a range of unique physical and chemical properties due to their small size effect.For example,lamellar montmorillonite could be used as an additive to enhance the lubricating properties of base oils.Hydroxyapatite,a major inorganic component of human bone,could be added to composites as a reinforcing material to enhance the biological activity of the material.The main objective of this paper is to construct a laminar liquid crystals lubrication system based on three components of nonionic surfactants Tween 80,Tween 85 and water,combining good lubricity and drug delivery performance by solubilizing drug molecules.The lubrication performance of the laminar liquid crystal was enhanced by compounding montmorillonite and in situ synthesis of hydroxyapatite.By investigating the lubricity and drug release behavior of the laminated liquid crystals during friction,providing the theoretical basis for the use of laminated liquid crystals in joint lubrication and synergistic treatment of arthritis.It is mainly divided into three parts as follows:(1)The three-component partial phase diagram of the Tween 85/Tween 80/H2O was drawn,the rheological and lubricating properties of the lamellar liquid crystals of the Tween 85/Tween 80/H2O system were investigated.The microstructure of the Tween 85/Tween 80/H2O lamellar liquid crystals were studied by small-angle X-ray scattering.The drug release model during the friction process was established,and it was found that the release rate of ibuprofen could be controlled by adjusting the ratio of the Tween 85/Tween 80 in the lamellar liquid crystals.At a constant load,the release rate and cumulative release of ibuprofen gradually increased with increasing of friction frequency;at a constant frequency,the load had less effect on the release rate and cumulative release of ibuprofen.(2)The lamellar montmorillonite(MMT)was introduced as an additive into the Tween 85/Tween 80/H2O lamellar liquid crystals to prepare the MMT/Tween 85/Tween 80/H2O lamellar liquid crystals.The effects of MMT content on the structure and lubricating properties of the Tween 85/Tween 80/H2O lamellar liquid crystals were investigated.The mechanism of friction reduction and anti-wear of MMT as an additive in lamellar liquid crystals were explored by analyzing the X-ray photoelectron spectra on the surface of abrasion marks.The results showed that the introduction of MMT could improve the lubricating properties of the Tween 85/Tween 80/H2O lamellar liquid crystals.Drug release experiments showed that the release rate of ibuprofen gradually increased with the increasing of friction frequency,while it was less affected by the load.(3)Using the soft template effect of the Tween 85/Tween 80/H2O lamellar liquid crystals,hydroxyapatite(HAP)was synthesized in situ using calcium nitrate and disodium hydrogen phosphate as the master batch to prepare the HAP/Tween 85/Tween 80/H2O lamellar liquid crystals.The effect of HAP concentration on the structure and lubricity of Tween 85/Tween 80/H2O lamellar liquid crystals were investigated.The mechanism of friction reduction and anti-wear of the HAP/Tween 85/Tween 80/H2O lamellar liquid crystals were explored by analyzing the X-ray photoelectron spectra on the surface of abrasion marks.The results showed that the introduction of HAP could improve the lubrication performance of the Tween 85/Tween 80/H2O lamellar liquid crystals.Drug release experiments showed that the release rate of ibuprofen gradually increased with the increase of friction frequency,while it was less affected by the load.