Construction Of Modified Electrodes Based On Gold Nanomaterials And Their Application Of Detection Of Drug Molecules

Drug molecules have been widely used to prevent or treat various human diseases and play an important role in the health of living organisms.However,the content of drug molecules in the body is too high or too low,which will cause biological metabolic disorders.Therefore,real-time monitoring of drugs is essential.It is necessary to accurately and efficiently analyze their concentration levels to determine whether the medication is safe and effective.The electrochemical analysis method has received widespread attention because of its low cost,high efficiency,rapid response,and high monitoring sensitivity.In this study,gold nanoparticles are compounded with other materials.After experiments,it is found that the efficiency,performance,capacity and cycle stability of the binary composite materials have been significantly improved.Experimental materials such as graphene oxide,chloroauric acid,and L-serine are used to construct multiple types of electrochemical sensors in this research.The research content can be divided into the following three parts:1.The chloroauric acid solution and graphene oxide（GO）powder are mixed and dispersed to obtain a deposition solution.By electrochemical reduction deposition,reduced graphene oxide（r GO）and gold nanoparticles（Au NPs）are formed on the surface of the glassy carbon electrode（GCE）.Prepared an electrochemical sensor based on r GO-Au NPs/GCE.Analyze dopamine（DA）by cyclic voltammetry（CV）and differential pulse method（DPV）.The results show that in the range of 1.0×10^-5～9.0×10^-4mol/L,the oxidation peak current value of DA has a good linear relationship with the concentration,and the detection limit（LOD）is 1.0×10^-8mol/L.2.The preparation of the r GO-Au NPs/GCE modified electrode for the determination of metronidazole（MTZ）is achieved by a simple single-step electrochemical reduction method,and the CV method and DPV method are used to explore the MTZ on the sensor.The electrocatalytic activity.The study found that the detection concentration is in the range of 3.0×10^-5～1.0×10^-4mol/L,the reduction peak current of MTZ has a good linear relationship with the concentration,and the detection limit is 1.0×10^-8mol/L.L.The prepared composite electrode can be used for the detection of actual samples.The recovery rate of MTZ in metronidazole tablets is determined.The results show that the sensor has high stability,sensitivity and recovery rate,and can be used for actual samples.Determination.3.The modification of L-serine on the bare glassy carbon electrode is achieved by environmentally friendly electropolymerization to obtain a PLS/GCE modified electrode,which is then loaded with gold nanoparticles by a potentiostatic deposition method.Au NPs/PLS/GCE composite modified electrode.Use this sensor to study the electrochemical behavior of gallic acid（GA）.The results showed that the peak current ofGA has a good linear relationship with the concentration of GA in the range of 3.0×10^-5～5.0×10^-4mol/L,and the detection limit was 3.0×10^-8mol/L.The sensor exhibits excellent sensitivity,better stability,etc.,and the recovery rate of the actual sample is better.