Studies On Thiourea-promoted 1,6-addition Reaction Between Indoles And Para-quinone Methides And The Synthesis Of Xanthone Via Visible-light Photoredox Reaction

In this thesis,we firstly described recent advances of 1,n-addition reactions promoted by thiourea as hydrogen bond donor catalyst.Then we studied the 1,6-addition reaction of indoles to para-quinone methides which was promoted by Schreiner thiourea as hydrogen bond donor catalyst.And we also studied the synthesis of xanthone via visible-light photoredox reaction.The thesis was divided into three chapters.Chapter 1 Research Progress of 1,n-Addition Reaction Promoted by Thiourea as Hydrogen Bond DonorIn this chapter,we briefly reviewed the recent advances of 1,n-addition reactions promoted by thiourea as hydrogen bond donor catalyst.This review was organized according to the types of reaction substrate and reaction patterns.Chapter 2 Schreiner Thiourea Promoted 1,6-Addition Reaction between Indoles and para-Quinone methidesIn this chapter,we developed a new method to promote the 1,6-addition reaction between indoles and para-quinone methides using Schreiner thiourea as hydrogen bond donor catalyst.The reaction featured mild conditions,wide substrate scope and transition metal-free condition.Based on experimental analysis and literature reports,we proposed the possible mechanism of the reaction.Chapter 3 The Synthesis of Xanthone via Visible-light Photoredox ReactionIn this chapter,we mainly developed a new method to prepare xanthone,an important chemical product from o-hydroxybenzaldehyde,which was promoted by visible-light-mediated reaction.The reaction featured mild conditions and avoiding the use of high temperature.Based on experimental analysis and literature reports,we proposed the possible mechanism of the reaction.