Study On Preparation And Performance Of Multifunctional Wound Dressing

In recent years,the research on wound dressings and their medical applications have attracted more and more attention,and has become a hot research topic in the field of medical materials.In fact,human research on wound dressing has a long history and has never stopped.At present,traditional dressings such as gauze,etc.,which are mainly used in clinical practice,are dry materials,which are easy to adhere to wound tissues and have poor anti-infection ability,which cannot meet the increasingly complex medical needs of the current world development.Inspired by the concept of moist wound treatment,more and more new wound dressings have been researched,such as polyurethane foam and film,alginate fiber dressing,hydrogel dressing,hydrocolloid dressing,etc.From the current research and development of new types of wound dressings,we can find that bionic materials,polymer materials and composite materials are becoming more and more popular,and wound dressings are increasingly required to play the role of emergency care and have more functions.Therefore,how to ensure that the wound dressing has enough functions and make the wound dressing have suitable physical properties requires more research on synthetic materials and methods.Based on these comprehensive considerations,the purpose of this research is to prepare a biomimetic composite polymer wound dressing with suitable physical properties,and to make it have a variety of functionalities that are beneficial to practical medical applications.The specific work content is as follows:1.The ideal wound dressing should have robust physical and biological properties.Inspired by the green chemistry concept of natural deep eutectic solvent(NADES),this study explored a simple and environmentally friendly method to prepare multifunctional wound dressing hydrogels based on NADES.First of all,the best solvent for the synthesis of target hydrogels is obtained by trying to synthesize natural eutectic solvents from different ratios of choline chloride and mannose.Then,DES-HD-DA hydrogel was obtained by crosslinking reaction of self polymerized monomer hydroxyethyl methacrylate(HEMA),methacrylic acid two methylamino ethyl ester(DMAEMA),Dobaamine(DA)and natural deep eutectic solvent under suitable conditions.In vitro experiments showed that the hydrogel had outstanding cell compatibility and antibacterial properties.Meanwhile,the mouse model skin damage experiment showed that the hydrogel strongly promoted wound healing.These results indicate that this research has successfully prepared a promising wound dressing hydrogel based on NADES,which can be applied to future medical materials.2.How to make products environmentally friendly while ensuring product functionality is becoming a crucial and burning issue in the manufacturing industry.In order to solve the problems related to environmental protection,this study explored the preparation of a natural,biodegradable and environmentally friendly hydrogel wound dressing using aloe as an active ingredient.In this study,the hydrogel wound dressing was made entirely of pure natural ingredients,including sodium hyaluronate(SH),dopamine(DA),chitosan(CS)and aloe(AV),and the natural deep eutectic solvent(NADES)was used as the green solvent substrate.The resultant DES-SH-CS/DA/AV hydrogel was easy to degrade and the preparation process was environmentally friendly.Afterwards,the physical and chemical properties of the hydrogel samples were characterized.The DES-SH-CS/DA/AV hydrogel showed good cytocompatibility tested using NIH-3T3 fibroblast cells,and antibacterial properties against both gram-positive(S.aureus)and gram-negative(E.coli).Furthermore,the hydrogel promoted skin tissue regeneration healed the wound of mouse skin after surgery within 12 days.These results confirm that DES-SH-CS/DA/AV hydrogel with potential of natural green wound dressing has been successfully prepared in this study.