The Synthesis Of Functional Organic Molecules Based On Enamides

This paper focuses on the chemical reactions of enamides,mainly introduces the research progress of enamides chemistry in recent years and the synthesis of several small organic molecules based on enamides,and mainly in order to prove the important role of enamides in organic synthesis,enriching the content of enamides chemistry.This paper included these six parts of works:The first work:Regioselective phosphorylation of tertiary enamides promoted by Lewis acidIn this chapter,we introduced a method to achieve regioselective phosphorylation of tertiary enamides by changing the type of Lewis acid,synthesizing a series ofα-phosphorylated amides andβ-phosphorylated tertiary enamides.The reaction uses inexpensive Fe Cl₃and Mn（acac）₃to initiate the reaction,which not only enriches theβ-phosphorylation reaction of the enamides,but also realizes theα-phosphorylation reaction of the enamides for the first time.The second work:The synthesis of isoindoloisoquinoline and benzoindolizinoindole derivativesIn this chapter,we introduced a method for the synthesis of isoindoloisoquinoline and benzoindolizinoindole derivatives by a one-pot method without metal catalysis.Under the catalysis of p-toluenesulfonic acid,the target product can be obtained by refluxing in toluene with electron-rich arylethylamine and o-acylbenzoic acid,and the product can be obtained by two simple operations to obtain nitrogen-containing nine-membered ring compounds.The third work:Catalyst-free one-pot cascade cyclization for the synthesis of isoindolobenzoxazinones and isoindoloquinazolinones derivativesIn this chapter,we introduced a catalyst-free cyclization of o-acylbenzoic acid with amino alcohols or diamines,and synthesizes isoindolobenzoxazinones and isoindoloquinazolinones derivatives in one-pot.This reaction is simple to operate,does not use a catalyst,environmentally friendly and has high atomic utilization.The fourth work:Intramolecular nucleophilic reaction of tertiary enamide for the synthesis of pentasubstituted pyrroles derivativeIn this chapter,we introduced a gold-catalyzed reaction of tertiary enamide tethered an alkynyl group to form pentasubstituted pyrroles.The reaction time is short,and it takes only 20 minutes to obtain pyrrole compounds with high yields,and providing a completely new method for the synthesis of polysubstituted pyrroles.