Development Of A Whole-Eye Tissue Parameter Measurement System Based On Swept Source Optical Coherence Tomography

With the increase of aging and the abuse of electronic devices,more and more people suffer from eye diseases,such as cataracts,refractive errors(nearsightedness and presbyopia),glaucoma,and fundus diseases.Whether in the surgical treatment of cataract patients or in the diagnosis of refractive errors such as myopia and presbyopia,it is necessary to measure the biological parameters of the eye tissue,especially the axis length and the curvature of the cornea.The measurement of ocular tissue parameters is important for the diagnosis and treatment of ophthalmic diseases.Among the commonly used methods for measuring biological tissue parameters,non-invasive,non-contact,and high-resolution optical measurement methods have gradually become a trend.At present,the experimental research on the optical measurement method of eye tissue has made certain progress.There are many optical biometers in clinical practice,but there are still immature parts,such as the inability to image the whole eye,the image needs to be stitched,and the types of measured parameters are not comprehensive.In response to the above problems,we proposes a high-resolution,large-range imaging,and high-precision optical biometric method.It provides a reliable method for the diagnosis and treatment of ophthalmic diseases.This paper develops a whole-eye tissue parameter measurement system based on swept frequency source optical coherence tomography technology,which is used for whole-eye imaging and accurate measurement of eye tissue parameters.The system uses a swept source laser with a center wavelength of 1060 nm based on the vertical cavity surface emitting laser technology as the light source,and integrates an internal fixation component and a video monitoring component.Scanning and synchronous sampling are controlled by the C++programming system,and the collected data is uploaded to the computer through the data acquisition card for processing,obtaining the spatial structure information of the target organization,and generating 2D images.This paper uses the whole-eye tissue parameter measurement system for preexperiment and human eye tissue parameter measurement experiment.The preliminary experiment mainly measures the distance information calibrated everywhere in the simulated eye and the curvature information of the plano-convex lens.The human eye measurement experiment is mainly divided into the length measurement experiment to measure the axis length and the curvature measurement experiment to measure the corneal refractive power.In this paper,according to the eyeball structure and the refractive index theory of each tissue,the length and curvature are measured on the 2D image,and the data of the corresponding ocular tissue parameters are calculated.To verify the accuracy of the measurement system,the measurement result is compared with the measurement data 700 of IOL Master.Through linear regression analysis and evaluation,the measurement results of this system and IOL Master 700 have consistency,indicating that the developed whole-eye tissue parameter measurement system realizes the accurate measurement of ocular tissue parameters such as axial length and corneal curvature.It meets the requirements of clinical measurement and has potential application value in the diagnosis and prevention of ophthalmic diseases.