Effect Of Intranasal Butorphinol And Dexmedetomidine On Emergence Agitation In Patients Undergoing Nasal Endoscopic Surgery

Objective:To investigate the effect of preoperative intranasal medication of combination of butorphanol and dexmedetomidine on the incidence of emergence agitation in patients undergoing nasal endoscopic surgery.Methods:One hundred and twenty patients aged 18-55 years(ASA I-II,BMI 18-29 kg/m~2)undergoing nasal endoscopic surgery were randomly divided into four groups(n=30),group M(intranasal medication butorphanol 15ug/kg+dexmedetomidine 0.8ug/kg);group B(intranasal medication butorphanol 20ug/kg);group D(intranasal medication dexmedetomidine 1ug/kg);group N(intranasal medication saline),and the four groups of medicinal solutions were respectively configured into a volume of 1.5m L.After 20 minutes,all patients were given anesthesia induction.Anesthesia was maintained by propofol and remifentanil.After the operation,all patients were sent to Postanesthesia care unit,reviving naturally.Vital signs(HR,MAP),Ricker score(VAS),extubation time,in the PACU time,amount of anesthetic drugs,amount of bleeding,operation time,the incidence of agitation and cough response,and adverse reactions were separately recorded.Results:There were no difference of general information among four groups(P>0.05).Compared with group N(53.5%),the incidence of emergence agitation was significantly decreased in group M(0%),group B(20.0%),and group D(23.3%)(P<0.05);and that of group M was lower than that in group B and group D(P<0.05).Compared with group N(86.7%),the incidence of cough response in group M(10%),group B(33.3%),and group D(30.0%)was significantly decreased.The amount of anesthetic drugs in group M was significantly less than that in groups B,D and N(P<0.05).Compared with group D,the incidence of bradycardia was decreased in group M and group B(P<0.05).The incidence of vomiting in group M,group B and group D was lower than that in group N(P<0.05).The incidence of drowsiness was no difference among the four groups(P>0.05).Conclusion:The combination of butorphanol and dexmedetomidine can provide better efficacy than either alone in decreasing the incidence of emergence agitation and complications of patients undergoing nasal endoscopic surgery by preoperative intranasal medication.