| PurposeTo explore the diagnostic efficacy of S-Detect computer-aided diagnostic system in differentiating benign and malignant thyroid nodules of the moderately & highly suspicious thyroid nodules classified by ACR TI-RADS,and to evaluate the clinical application value of S-Detect computer-aided diagnostic system.Methods:A total of 137 patients,157 nodules in total,who were diagnosed as the moderately & highly suspicious thyroid nodules(TR4-TR5)according to ACR TI-RADS classification criteria by the operator during thyroid ultrasound screening in our department from July 2019 to November 2020 and were prepared for ultrasound-guided FNA or CNB examination were selected.After the image information was fully retained,initial diagnosis of all nodules was performed by the S-Detect computer-aided diagnostic system and by two groups of physicians of different seniority(two in each group and none of them were ultrasound screening operators).The S-Detect diagnosis results were then presented to each doctor,and all the nodules were re-diagnosed by doctors of different seniority upon reference to the S-Detect diagnosis results.Finally,the results of pathological diagnosis were used as the "gold standard" to analyze and compare the differences of diagnostic efficacy between different groups and different methods.Results:In comparison to the diagnostic efficacy of doctors with low years of experience,the sensitivity,specificity,positive predictive value,and negative predictive value(94.8%,45.2%,82.6%,76.0%)of the diagnostic results of S-Detect computer-aided diagnosis system were higher than those of doctors with low years of experience(Doctor 1:91.3%,16.7%,75.0%,41.2%,Doctor 2:84.3%,28.6%,76.4%,40.0%),the results were statistically different between the two.In comparison to the diagnostic effectiveness of doctors with senior experience,the diagnostic effectiveness of S-Detect computer-aided diagnosis system was lower than that of doctors with senior experience(doctors 3:98.3%,47.6%,83.7%,90.9%,and doctors 4:97.4%,54.8%,85.5%,88.5%),and there was no statistical difference between the two results.After reference to the S-detect diagnosis and re-diagnosis,the diagnostic efficacy of both junior physicians improved(doctors 1:96.5%vs 91.3%,38.1% vs 16.7%,81.0% vs 75.0%,80.0% vs 41.2%;Doctor2:92.2% vs 84.3%,64.3% vs 28.6%,87.6% vs 76.4%,75.0% vs 40.0%),the results were statistically different between the two.The sensitivity of seniority doctors to the 3 diagnosis was the same as before the S-detect diagnosis(98.3% vs 98.3%),The specificity,positive predictive value,and negative predictive value were slightly lower than before the reference S-detect diagnosis(45.2% vs 47.6%,83.1% vs 83.7%,90.5%vs 90.9%),and there was no statistical difference between the two.The sensitivity and negative predictive value of seniority 4 were slightly lower than before(93.0% vs 97.4%,77.8% vs 88.5%),while the specificity and positive predictive value were improved(66.7% vs 54.8%,88.4% vs85.5%).There was no statistical difference between the two results.After considering the S-Detect diagnosis,there was no statistically significant difference in diagnostic efficacy between the group of doctors with low seniority and the group with high seniority.Conclusion:1.In terms of diagnostic effectiveness of differentiating benign from malignant thyroid nodules at the moderately & highly suspicious thyroid nodules,the diagnostic effectiveness of S-Detect computer-aided diagnosis system can reach the level of imaging doctors with senior experience.2.After referring to the diagnostic results of S-Detect,the S-Detect computer-aided diagnostic system can significantly improve the diagnostic performance of low-experience imaging doctors.3.S-Detect as a computer-aided diagnosis system,can provide reliable reference for ultrasonographic diagnosis of the moderately &highly suspicious thyroid nodules... |
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