Short-term Effect Analysis Of Laparoscopic Single Anastomosis Duodeno-ileal Bypass With Sleeve Gastrectomy On The Treatment Of Obesity And Obesity-related Metabolic Diseases

Background and purpose:It has been proved that laparoscopic single anastomosis duodeno-ileal bypass with sleeve gastrectomy(LSADI-S),as a relatively new operation,is safe and effective for obesity in some countries.However,there is little research in China.Our study aims to evaluate the clinical short-term effect of LSADI-S on the treatment of patients with obesity and obesity-related metabolic diseases.Methods:Preoperative clinical characteristics and 3 to 12 months of postoperative data were collected and analyzed.The clinical data of 22 patients who underwent LSADI-S at our hospital from October 2018 to December 2019 were analyzed retrospectively.The short-term effects of the surgery on body mass,body mass index,fasting blood glucose,glycosylated hemoglobin,blood pressure,uric acid,and blood lipids were analyzed.Results:A total of 22 patients were treated successfully with LSADI-S without conversion to open surgery,serious complications,and perioperative death.The weight,waist circumference,and body mass index(BMI)of the patients decreased significantly at 3 and 6 months after surgery(P<0.05).At 3 and 6 months after surgery,the complete remission rate of type 2 diabetes(T2D)was 80% and 100%,and the partial remission rate of T2 D was 20% and 0%,respectively;the complete remission rate of hyperlipidemia was 33.3% and 50%,respectively;the complete remission rate of hyperuricemia was 20.0% and 40.0%,respectively;the complete remission rate of obstructive sleep apnea was 83.3% and 88.9%,respectively;the complete remission rate of hypertension was 80.0% and 84.6%,respectively.Majority of patients had vitamin,trace element and nutrition levels in the normal range.One case presented internal jugular vein thrombosis and was healed after medication.Conclusion:LSADI-S has a significant effect on the treatment of obesity and obesity-related metabolic diseases in the short term after surgery.However,multicenter randomized controlled studies with larger sample sizes and comparison with the current mainstream weight loss surgeries in the world are needed to explore the long-term safety and efficacy of SADI-S.