| Objective:To observe the clinical effect of Wufang San combined with western medicine in the treatment of rheumatoid arthritis(RA)patients with cold and dampness arthralgia syndrome,and to provide the basis for the treatment of cold and dampness arthralgia syndrome RA with integrated Chinese and western medicine.Methods:By selecting 50 patients from January 2019 to September 2020 in the outpatient and inpatient department of Rheumatology,the first Clinical Medical College of Guangxi University of traditional Chinese Medicine meet the RA of cold and dampness obstruction,It is divided into treatment group and control group according to random number table method,Comparability.The control group was given methotrexate 10 mg qw meloxicam 7.5 mg bid oral treatment,On the basis of the control group,the treatment group was treated with Wufang San,three times a week,4 h,each For 12 weeks,VAS pain score,joint swelling number,tenderness number,morning stiffness time score,TCM syndrome score,Laboratory indicators CRP、ESR、RF 、C3、C4and changes DAS28 、 CDAI disease activity,To evaluate the clinical efficacy of Wufang San external application combined with western medicine in the treatment of cold and dampness obstruction type RA patients.Results:(1)The total effective rate of treatment group was 92%,The total effective rate in the control group was 80%,Compare the two groups,difference was statistically significant(P<0.05);(2)Comparison of pain scores between the two groups: the VAS scores of the two groups decreased after treatment compared with those before treatment,difference was statistically significant(P<0.05);And after treatment,the VAS score of the treatment group was better than that of the control group,difference was statistically significant(P<0.05).(3)Comparison of symptoms and signs of affected joints before and after treatment between the two groups: the number of joint tenderness,joint swelling and morning stiffness decreased after treatment,difference was statistically significant(P<0.05);And after treatment,the corresponding indexes of the treatment group were better than those of the control group,difference was statistically significant(P<0.05).(4)Comparison of TCM syndrome score between two groups before and after treatment: after treatment,The scores of joint pain,joint swelling,joint tenderness,morning stiffness,joint flexion and extension were lower in the treatment group and control group than before,difference was statistically significant(P<0.05),And after treatment,the corresponding indexes of the treatment group were better than those of the control group,difference was statistically significant(P<0.05);After treatment,The symptoms of cold joint in the treatment group were better than before,difference was statistically significant(P<0.05),Before and after treatment,(P>0.05),After treatment,the cold score of joint was better than that of control group,difference was statistically significant(P<0.05);After treatment,The symptoms of cold and warm limbs in the treatment group were better than before,difference was statistically significant(P<0.05),Control group before and after treatment no significant difference(P>0.05);The treatment group had no advantage over the control group,and the difference was not statistically significant(P>0.05).(5)Comparison of laboratory indexes between the two groups before and after treatment: the ESR、CRP、RF 、C3、C4level of the two groups decreased compared with that before treatment,difference was statistically significant(P<0.05);And after treatment,the CRP、ESR value of the treatment group was lower than that of the control group,difference was statistically significant(P<0.05);After treatment,there was no significant difference in RF、C3、C4 value between the treatment group and the control group,and the difference was not statistically significant(P>0.05).(6)Comparison of disease activity between the two groups before and after treatment: the DAS28 、CDAI score of the two groups after treatment decreased compared with that before treatment,difference was statistically significant(P<0.05);And after treatment,the DAS28、CDAI score of the treatment group was better than that of the control group,difference was statistically significant(P<0.05).(7)Evaluation of drug safety in both groups: no significant blood routine,liver and kidney function damage,The skin allergic reaction in the treatment group was rare.Conclusion:The clinical effect of Wufang Powder combined with western medicine in the treatment of cold and dampness arthralgia obstruction RA can effectively alleviate the joint symptoms and signs,improve the TCM syndromes of cold and dampness obstruction syndrome,and reduce the inflammatory reaction and disease activity.It is worthy of clinical application. |
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