Meta-analysis Of Adipose-derived Stem Cells In The Treatment Of Diabetic Foot Ulcer

Objective:To evaluated the efficacy of adipose-derived stem cells(ADSCs)in the treatment of Diabetic foot ulcer(DFU).Methods:First,relevant retrieval strategies were developed,and then relevant literature inclusion and exclusion criteria were developed.Finally,China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Database(VIP Database),Pub Med,Embase,Cochrane Library and other databases were searched.A comprehensive search of randomized controlled trials(RCTs)of adipogenic stem cells for diabetic foot ulcers was conducted from database establishment until December 2020,with the last update in February 2021.After literature screening,data extraction,literature quality assessment and bias risk assessment were conducted independently by two researchers,Review Manager5.4 software was finally used for literature quality assessment and Meta analysis.Results:A total of 5 randomized controlled trials were included,including 285 patients with diabetic foot ulcer,including 145 patients in the adipo-derived stem cell treatment group and 140 patients in the control group.The results of Meta-analysis showed that compared with the control group,the adipose derived stem cell treatment group decreased the number of days needed for wound healing of diabetic foot ulcer[MD value:-10.69,95%CI(-14.16,-7.21),P<0.00001,I~2=54%]and increased the wound healing rate of diabetic foot ulcer[OR value:5.31,95%CI(2.69,10.50),P<0.00001,I~2=14%],with statistical significance.It was suggested that adipose derived stem cells can benefit significantly in the treatment of diabetic foot ulcer and had significant advantages compared with the conventional treatment group.Conclusion:Adipose derived stem cells for diabetic foot ulcer is an effective treatment method,which can reduce the time required for wound healing,improve wound healing rate and promote wound healing in patients with diabetic foot ulcer.