| Objective To study the effects of cerebrospinal fluid flow(CSF)dynamics on Chiari malformation typeⅠ(CMI)and Syringomyelia,Phase-Contrast MRI(PC-MRI)was used to monitor the changes of CSF dynamics for normal volunteers and patients before and after surgery.Methods In this study,there were sixteen normal volunteers and seventeen patients with Chiari malformation type Ⅰ and syringomyelia.And these patients had undergone Posteriorfossa decompression(PFD);then,PC-MRI scans of their Craniocervical Junction(CVJ)were performed before and 12 months after surgery.The volunteers only need to be checked once.The following parameters in the central part of aqueduct of midbrain,the outflux tract of fourth ventricle and the horizontal position of epistropheus,need to be analyzed,such as the flow rate,the flow volume,etc.Meanwhile,combining with Chicago Chiari Outcome Scale(CCOS),we also studied these patients’ conditions of prognosis.Results In the central part of aqueduct of midbrain,the outflux tract of fourth ventricle and the horizontal position of epistropheus,the patients’ peak flow velocity of CSF increased and the overall flow volume decreased(P < 0.05),compared with normal volunteers.And12 months after the operation,their peak flow rate of CSF in these parts were significantly slower and the flow volume increased(P < 0.05).For the parameters of cerebrospinal fluid flow,different prognosis patients have different changes(P < 0.05),which was consistent with the scores and clinical outcome of CCOS.Conclusion Patients with Chiari typeⅠmalformation and syringomyelia have dynamic changes in cerebrospinal fluid,which are manifested as obstruction of cerebrospinal fluid flow.The improvement of cerebrospinal fluid flow dynamics is closely related to the prognosis of patients.And as described in this article,PC-MRI can be used to evaluate the prognosis of patients with Chiari malformation type Ⅰ and syringomyelia,combining with CCOS. |
