Correlation Analysis Of GFAP And Tau In Serum Of Traumatic Brain Injury Patients On The Degree Of Traumatic Brain Injury And Cognitive Impairment

BackgroundTraumatic brain injury(TBI)is a direct or indirect brain injury to the head caused by a series of external forces,including head injuries,head injuries,motor vehicle accidents or domestic violence.Glial fibrillary acidic protein(GFAP)is an intermediate filamentous protein of astrocyte skeleton,which has been used to assess the severity and prognosis of acute TBI injury.Tau protein is a member of the microtubule-associated protein family.It is currently believed that the abnormal accumulation of Tau protein is related to chronic traumatic encephalopathy and traumatic brain injury.This study provides a basis for the diagnosis and efficacy of traumatic brain injury through the study of these two biomarkers.ObjectiveTo investigate the correlation analysis of serum GFAP and Tau protein in patients with traumatic brain injury on the degree of traumatic brain injury and cognitive impairment.MethodsA total of 87 patients with traumatic brain injury who were hospitalized in our hospital were selected as the observation group from June 2019 to June 2020,and healthy subjects were selected as the control group.Serum GFAP and Tau levels of patients with different degrees of injury were measured by ELISA,and the correlation between GFAP and Tau protein levels and cognitive impairment was analyzed.ResultAfter 1 month,2 months and 3 months of treatment,the GFAP and Tau protein levels of the observation group were higher than those of the control group(P<0.05);the GFAP and Tau protein levels of the observation group with MCI(mild cognitive impairment)were higher than those of the control group and the observation group without MCI(P<0.05);the serum GFAP level of the observation group with MCI was negatively correlated with MOCA score(r =-0.8747,P< 0.001).ConclusionsSerum GFAP and Tau levels in patients with traumatic brain injury are correlated with secondary cognitive impairment,and can be used as reliable biological indicators for early diagnosis of TBI and cognitive recovery.