| Objective:To analyze the cognitive function characteristics of elderly patients with type 2 diabetes mellitus(T2DM)complicated with sleep disorders,and to clarify the influence of sleep conditions on cognitive function of elderly patients with type 2 diabetes mellitus(T2DM).Methods:A total of 90 patients were included,including 42 T2DM patients with sleep disorders(SD),28 T2DM patients alone,and 20 normal control patients(NC).The Mini-mental state examination(MMSE),the Montreal Cognitive Assessment Scale(MoCA),and the Pittsburgh Sleep Quantity(PSQI)were used for detection in all three groups.The results were compared by multi-group analysis of variance and multiple linear regression.Results:MoCA,MMSE and PSQI scores among the three groups were expressed as mean ±standard deviation.MoCA score(18.41±1.84),MMSE score(24.12±1.21)and PSQI score(9.81±1.97)in the T2DM combined with SD group were respectively(18.41±1.84),(24.12±1.21)and(9.81±1.97).MoCA score(21.89±1.71),MMSE score(26.07±1.15),PSQI score(2.61±1.55)in T2DM group;In the NC group,MoCA score was(25.80±1.54),MMSE score was(28.20±0.95),and PSQI score was(2.10±1.45).Compared with T2DM combined with SD group and NC group,there were statistically significant differences in MoCA,MMSE and PSQI scores(P < 0.05).There were significant differences in the total MoCA scores between T2DM combined with SD group and T2DM alone group as well as between T2DM alone group and NC group(P < 0.05).In the scores of each MoCA subitem,the visual space and executive ability,naming,attention,language and delayed recall scores of T2DM combined with SD group were significantly different from those of T2DM alone group(P < 0.05).Compared with the NC group,there were statistically significant differences in visual space,executive ability,attention,language and delayed recall scores between the T2DM group and the NC group(P< 0.05).There were significant differences in the total MMSE scores between T2DM combined with SD group and T2DM alone group as well as between T2DM alone group and NC group(P < 0.05).In the scores of each MMSE subitem,there were statistically significant differences in orientation,memory,recall ability and language ability between T2DM combined with SD group and T2DM group alone(P < 0.05),and statistically significant differences in recall ability and language ability between T2DM group and NC group alone(P < 0.05).The total PSQI scores of T2DM combined with SD group and T2DM alone group showed statistically significant difference(P < 0.05).In all subitems of PSQI,except hypnotic drugs,there were statistically significant differences in other subitems(P <0.05).There was no statistically significant difference in the total PSQI score between the T2DM group and the NC group(P > 0.05),while there was statistically significant difference in the score of sleep disorders(P < 0.05).Multiple linear regression showed that PSQI score,duration of diabetes,years of education and fasting blood glucose(FBG)were independent risk factors affecting cognitive function in elderly patients with T2DM and SD.Conclusion:The elderly patients with T2DM combined with sleep disorders had cognitive impairment in many cognitive domains.Compared with patients with T2DM alone,the cognitive decline was more obvious in visuospatial and executive ability,naming,attention,language,delayed recall and other domains.Sleep disturbance can further aggravate cognitive impairment in elderly patients with type 2 diabetes. |
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