Effects Of Metabolic Syndrome And Its Components On Biological Characteristics Of Primary Liver Cancers

Objective: To investigate the relationship between metabolic syndrome(MetS,including triglyceride,high-density lipoprotein,hyperglycemia,hypertension),cholesterol and primary liver cancers.Methods: 191 patients clinically diagnosed as primary liver cancers who received treatment in the Shenzhen Second People’s Hospital during 2011 and 2020 were selected.Clinical data including age,gender,blood pressure,blood biochemistry,imaging report and postoperative histopathology,were collected and analyzed,retrospectively.The significance of differences in clinical features between MetS and non-Mets groups were performed by the t test.The relationship between biological characteristics of HCC and MetS were performed Binary and multivariate logical analysis.Results:(1)In t-test between MetS and non-MetS,the significant difference of intrahepatic metastasis,cancer embolus,lymphatic metastasis were detected.(59.3% vs 16.4%,46.9% vs12.7%,30.9% vs 2.7%,p < 0.001).Decreased TG was preoperative risk factors of intrahepatic metastasis(OR 5.210 CI:2.199,12.344 p<0.001),decreased CHO was preoperative risk factors of cancer emboluscancer embolus(OR 2.700 CI : 1.029,7.083p=0.044).(2)When MetS met with no more than 3 diagnostic criteria,the crowd(cancer embolus and lymphatic metastasis)increased with the number of MetS components;when more than 3 diagnostic criteria,the crowd decreased.(3)The significant difference of cholangiocarcinoma between MetS and non-MetS was detected.(33.3% vs 2.0%,p<0.001).Conclusion:(1)MetS was risk factor of adverse biological characteristics of primary liver cancers.Low triglycerides and low cholesterol were risk factors of the poor prognosis.(3)When MetS met with no more than 3 diagnostic criteria,the probability of the occurrence of adverse biological characteristics of primary liver cancers was positively correlated with the numbers of diagnosis;When greater than 3,the probability was negatively correlated.(3)MetS was associated with increased risk for cholangiocarcinoma.