Dietary Patterns And Hyperuricemia In Adult Residents In Hebei Province

Background: Hyperuricemia can cause gout and is associated with hypertension,dyslipidemia,heart disease and other cardiovascular diseases..With the development of economy and the change of life style,the prevalence of hyperuricemia shows an upward trend.Although we know there is a strong relationship between diet and hyperuricemia,the relationship between dietary patterns and hyperuricemia is still poorly understood.Objective: The purpose of this study is to investigate the prevalence and demographic characteristics of hyperuricemia among adult residents in Hebei Province through a nutritional epidemiological survey,and to explore the relationship between dietary patterns and hyperuricemia.Methods: A multi-stage stratified cluster sampling method was used to select four survey sites in Shijiazhuang City,Tangshan City,Lincheng County and Cangxian County of Hebei Province.One urban site and one rural site were selected from each survey site to conduct a questionnaire survey among the permanent resident population.Collected information about general demographic,lifestyle,history of disease,dietary intake.Physical measurements and blood tests were performed on the subjects.Dietary patterns were extracted by principal component analysis(PCA)and reduced rank regression(RRR).Logistic regression analysis was performed between hyperuricemia and dietary pattern scores to explore the relationship between dietary pattern and hyperuricemia.Results: The prevalence of hyperuricemia was 19.3%,and there were statistical differences in the detection rate of hyperuricemia among people with different ages,genders,places of residence,education levels,alcohol consumption,obesity,hypertension and dyslipidemia(P < 0.01).Principal component analysis(PCA)obtained three dietary patterns:balanced fruits and vegetables,processed snacks and animal foods.The characteristics were as follows: balanced fruits and vegetables: more intake of fresh vegetables,fruits,milk,eggs,beans and their products;processed snacks:more intake of processed meat,snacks,bacteria,algae and pickled processed vegetables;Animal food: more intake of poultry meat,livestock meat,fish and shrimp,processed meat and nuts.A pattern of high uric acid diet characterized by higher intake of poultry meat,animal offal and sugar-sweetened beverages was obtained by descending rank regression.Logistic regression analysis after adjusting for confounding factors showed that a balanced fruit and vegetable diet was associated with a lower risk of hyperuricemia,and the risk of hyperuricemia in the quartile with the highest dietary pattern score was significantly lower than that in the quartile with the lowest dietary pattern score(OR=0.659,95%CI 0.572-0.823,P=0.003).The animal-based food dietary pattern was associated with a higher risk of hyperuricemia,and the quartile with the highest dietary pattern score had a significantly higher risk of hyperuricemia than the quartile with the lowest dietary pattern score(OR=0.659,95%CI 1.016-1.648,P=0.006);the processed snack diet pattern was not associated with the risk of hyperuricemia,and there was no statistically significant difference between the highest and lowest quartiles(OR=1.095,95%CI 0.855-1.354,P=0.219).The high uric acid diet pattern was associated with a higher risk of hyperuricemia,the quartile with the highest dietary pattern score having a significantly higher risk of hyperuricemia than the quartile with the lowest dietary pattern score(OR=1.531,95%CI 1.234-1.900,P < 0.001).Conclusions: Animal-based dietary pattern was associated with a higher risk of hyperuricemia.Balanced fruit and vegetable diet was associated with a reduced risk of hyperuricemia.Dietary pattern characterized by higher intake of poultry meat,animal offal,and sugary beverages was associated with an increased risk of hyperuricemia.