The Relationship Between IL-6,IL-10 And The Prognosis Of Postoperative Patients With Traumatic Brain Injury Or Cerebral Hemorrhage

Purpose: Traumatic brain injury and cerebral hemorrhage are common major neurosurgical emergencies,which require prompt emergency treatment and emergency surgery when necessary,and the prognosis is often poor.The concentration of cytokines is significantly increased in patients with cerebral accidents such as IL-6 and IL-10.This article intends to explore the possible risk factors which affect the outcome of patients with TBI or cerebral hemorrhage through statistical analysis.In order to supply reference for further therapy and predict the outcome of patients with TBI or cerebral hemorrhage through the level of various influencing factors in the early stage.To supply a basis for the precaution and therapy of SBI to TBI and cerebral hemorrhage from the molecular level in the future.Methods: The research objects are 46 postoperative patients with TBI or cerebral hemorrhage who were treated in the Department of Neurosurgery of the First Affiliated Hospital of China Medical University from 2019.4 to 2020.10.Collected the gender,age,type of cerebral accident,IL-6 serum level,IL-10 serum level,admission GCS score,the prevalence of diabetes,the prevalence of hypertension,pupil reflection to light,midline shift,these 10 factors may affect outcome.The outcome of patients was assessed by the GOS scale 3 months after the onset,and they were partition into a good recovery(4points,5 points)and a poor recovery(1 point,2 points,3 points).Use the SPSS 26 data processing program to perform a simple independent causal analysis of each factor,and integrate the possible influencing factors with obvious differences to perform logistic regression analysis.Results: 21 cases(46%)had a good recovery and 25 cases(54%)had a poor recovery.Independent factor analysis suggests that: IL-6 on the first day,IL-10 on the first day,admission GCS score,pupil reflection to light,and midline shift were different between the two comparison groups with different recovery,and the difference meets the statistical requirements(P<0.05).Gender,age,type of brain accident,prevalence of diabetes,and prevalence of hypertension between the two comparison groups with different recovery doesn’t meet the statistical requirements(P> 0.05).The logistic regression results suggests that IL-6 on the first day,admission GCS score,and midline shift were related factors affecting the prognosis,while on the first day IL-10,the difference in pupil reflection to light was not significant.Conclusion: The type of brain accident(TBI or cerebral hemorrhage)does not interfere with the study of the relationship between other possible influencing factors and prognosis.IL-6 on the first day,admission GCS score,and midline shift are risk factors that affect the outcome of postoperative patients with TBI or cerebral hemorrhage.IL-10 on the first day,the pupil’s light reflection has no significant effect.Gender,age,kind of brain accident,prevalence of diabetes,and prevalence of hypertension had no statistical significance on the prognosis.High IL-6 on the first day,low admission GCS score,midline shift will increase the risk of poor prognosis.