| Objectives To explore the relationship between frailty and polypharmacy in elderly patients with chronic diseases in the community hospitals.Methods In the case-control study,elderly patients(age,≥60 years old)with chronic diseases in stable condition in the community health service center affiliated to the Affiliated Hospital of X University from November 2019 to November 2020 were selected as the study subjects.Fried phenotype definition was used for frailty assessment with the following 5 indexes:weight loss,fatigue,slow walking speed,low gripping strength and low physical activity amount.According to the assessment results,the elderly patients in line with 3-5 indexes were identified as frailty group(case group),and the elderly patients in line with 0-2 indexes were identified as non-frailty group(control group).There were 47patients in the case group with an average age of 79.3±6.2 years old,including 20 males(42.6%)and 27 females(57.4%);and there were 85 patients in the control group with an average age of 70.7±7.2 years old,including 38 males(44.7%)and 47 females(55.3%).Clinical data were collected by means of questionnaire survey,including age,gender,education level,height,weight,smoking and drinking habits,living alone or not,patient’s condition,drug use condition,blood pressure,fasting blood glucose,blood lipid,etc.The collected data were used to establish a database,and SPSS22.0 statistical analysis software was selected for data analysis.Measurement data with normal distribution and homogeneity of variance was expressed as mean±SD,and the independent samples(or two-sample)t-test was used for mean value comparisons between groups.The enumeration data was expressed as"percentage",andχ~2 was applied to comparisons between groups.Logistic regression model was used for multivariate analysis.All tests were 2-tailed,and P<0.05 indicated that the difference was statistically significant.Results 1 According to the equilibrium analysis,there were significant differences in the age(79.3±6.2 vs.70.7±7.2)and the proportion of smoking cases(40.4%vs.23.5%)between the case group and the control group,and the education level in the case group was obviously lower than that in the control group(all P<0.05);the proportion of female,the proportion of drinking cases and the status of living alone were slightly higher in the case group when compared with the control group,but without significant difference(all P>0.05);the proportion of patients with≥3 diseases in the case group was significantly higher than that in the control group(89.4%vs.71.8%,P<0.05);and the proportion of patients with metabolic syndrome and malnutrition in the case group was obviously higher than that in the control group(P<0.05).2 The average number of drug use in the case group was significantly higher than that in the control group(6.5±2.4 vs.4.0±2.2,P<0.05);and the proportion of patients with polypharmacy in the case group was higher than that in the control group(P<0.05).3 Logistic regression analysis showed that,after excluding the interference of other factors,the relationship between frailty and polypharmacy was still statistically significant(P<0.05,OR=3.445),indicating that polypharmacy may increase the risk of developing frailty in the elderly patients with chronic diseases by nearly 2.5 times.Among influencing factors,the polypharmacy was second only to malnutrition as for the close relationship with frailty.Conclusions 1 There was a significant correlation between frailty and polypharmacy,and the elderly patients with chronic diseases combined with polypharmacy are more prone to developing frailty.2 Frailty was positively correlated to age,smoking,comorbidity,malnutrition and metabolic syndrome,and negatively correlated to education level.Figure 0;Table 11;Reference 132... |
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