| Objectives To observe the clinical efficacy of Baoshen Huoxue decoction combined with irbesartan in the treatment of G1A2 diabetic kidney disease(DKD)with qi-yin deficiency and blood stasis syndrome,to explore the effectiveness and safety of Baoshen Huoxue decoction tentatively.Methods The patients who met the criteria were included for treatment in the induction period.2 weeks later,the patients were screened and divided into experimental group(n=34)and control group(n=34)randomly.The control group was treated with irbesartan tablet orally,and the experimental group was additionally treated with traditional Chinese medicine decoction for 12 weeks,urinary albumin/creatinine ratio(UACR),cystatin C(Cys C),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)were examined before and after treatment,TCM syndrome score and quality of life score were evaluated,and related safety tests were conducted.Collected patient information and recorded data,filled in the case collection table,used spss 23.0 statistical software to analyze the data,after analyzing the data,conclusions are drawn and discussed.Statistical processing of data by using spss 23.0 statistical software;age,course of disease and body mass index(BMI)are measurement data,which do not accord with normal distribution,and rank sum test was used;Chi-square test was used for gender counting data;UACR,Cys C,TNF-α,hs-CRP,glucose and lipid metabolism index,blood pressure,TCM syndrome score,quality of life score,liver function,electrolyte and renal function were measurement data,and t-test was used in accordance with normal distribution;the curative effect of TCM syndrome integral and clinical curative effect were used as grade data,and the rank sum test was used.Results A total of 68 qualified cases were included in this clinical observation,a total of 2 cases fell off,and 33 cases in each group completed the test.1 Before treatment,there was no significant difference in age,course of disease,BMI,sex,urinary protein,Cys C,inflammatory factors,glucose and lipid metabolism,blood pressure,liver function,electrolyte,renal function,TCM syndrome score and quality of life score between the two groups(P>0.05).2 After treatment,there was no significant change in UACR,CysC,TNF-α and hs-CRP decreased significantly compared with before(P<0.05),and the decrease degree was higher in experimental group(P>0.05).There were no significant differences in glucose and lipid metabolism indexes and blood pressure between 2 groups before and after treatment(P>0.05).The score of TCM syndrome decreased compared with before(P<0.05),and the decrease of scores in experimental group was better than that in control group(P<0.05).The quality of life score decreased compared with before(P<0.05),and the decrease in the experimental group was higher than that in the control group(P<0.05).3 Compare the curative effect of the two groups of patients after treatment,the total effective rate of TCM syndrome was 90.91%in the experimental group and 66.67%in the control group(P<0.05).The total effective rate of the experimental group was 84.85%,while that of the control group was 63.64%.The effective rate of the experimental group in improving the efficacy of TCM syndromes and clinical efficacy was higher than that of the control group,with the difference was statistically significant(P<0.05).4 There were no significant changes in liver function,electrolytes,renal function and other safety indexes before and after treatment(P>0.05),and no adverse reactions were reported.Conclusions Baoshen Huoxue decoction combined with irbesartan can reduce urinary protein,reduce the levels of Cys C,TNF-α and hs-CRP,improve symptoms and improve quality of life in patients with kidney disease of stage G1A2 with qi-yin deficiency and blood stasis syndrome,and have not been found to have adverse effects on liver function,electrolytes and renal function,and it has certain security.Figure 0;Table 26;Reference 123... |
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