Effect Of Metformin On Adiponectin In Pcos:A Meta-Analysis And A Systematic Review

Background: Conflicting results regarding the effect of metformin on adiponectin levels in women with polycystic ovary syndrome(PCOS)have been reported.A meta-analysis and a systematic review of all studies comparing adiponectin levels before and after metformin treatment in women with PCOS were performed.Other indicators related to PCOS long-term complications such as inflammatory factors,hormonal parameters and metabolism profile were investigated.Methods: A literature search was conducted in the PUBMED,EMBASE,The Cochrane Library,CNKI and CBM databases.11 studies,containing data on 353 subjects,were included in the main meta-analysis.Results: Metformin treatment was associated with significantly increased serum adiponectin concentrations [10 studies,random-effects SMD(95% CI)-0.58 [-1.03,-0.13];I2=86%;P=0.01].The meta-analysis also revealed that circulating TNF-a and CRP concentrations were significantly decreased after metformin treatment,with corresponding SMDs of 1.01(95% CI: 0.74 to 1.28,P<0.00001)and 0.48(95% CI: 0.35 to 0.60,P<0.00001).Conclusion: Serum adiponectin concentrations of PCOS women was found to be significantly increased after metformin therapy.Adiponectin may be a potential marker for the efficacy of metformin.Further investigation with a larger sample size was needed to determine the optimal dose and duration.