The Pharmaceutical Research Of Kang Zhi Oral Liquid

Respiratory infectious diseases rampant,especially in prevention and treatment of mycoplasma Pneumoniae pneumonia(MPP)is always a difficult problem to one of the focuses of the medical profession at home and abroad.Mycoplasma pneumoniae infection,formerly known as primary atypical pneumonia,caused by mycoplasma pneumoniae infection,the basic pathology showed interstitial pneumonia or bronchiolitis-like changes,clinical manifestations characterized by intractable coughing More incidence of children,the clinical commonly used antibiotics,clinical frequent adverse reactions such as rash and vomiting,at the same time,due to the liver and kidney function in children with immature,long-term use of antibiotics on liver and kidney damage.Therefore,it is particularly important to develop a treatment of MPP Chinese medicine specificSupport for the Kang-Zhi oral liquid clinical experience side by ephedra herb,radix stemonae,celandine,rhizoma belamcandae,almond,platycodon grandiflorum,Oriental arborvitae,white mulberry root-bark,licorice,Based on a sense of the disease,pharyngitis,tonsillitis caused by the treatment of Mycoplasma pneumoniae infection and bronchitis,bronchitis,pneumonia caused by the treatment of downstream infection for the primary purpose of the drug.The party in the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine treatment of pediatric Mycoplasma pneumoniae infections get better treatment effect.This topic according to the research of new drug of TCM guide six kind of requirement of new drug of TCM,against the anti-bronchial oral liquid of extraction,purification,molding technology and quality standards were studied.And preliminary experimental study stability.In this paper,in terms of optimization of extraction process,total alkaloid content as indexes,compared the impact of the water,acid water,aqueous alcohol,ethanol and various solvents on the extraction process,the extraction efficiency of total alkaloids as follows:70%ethanol>95%ethanol>30%alcohol>Acid>water.Ｉn order to further compare the effect of the extract cough,the use of ammonia cited in mice cough test guidance process optimization,the results showed that in terms of control cough incubation period,the acid water group and ethanol group quite effective,but in the aspect of reducing the frequency of cough acidic water was significantly better than ethanol groups.So choose acid water as the extraction solvent.Refining process uses the classic water extract-alcohol precipitation,effectively improve the clarity and dose of the anti-bronchial oral liquid.After process validation,the anti-bronchial oral liquidpreparation stability,the preparation of the anti-bronchial oral liquid,appearance properties,relative density,pH value,the difference of filling quantity,hygiene,etc which adhere to the quality requirements of oral liquid.In addition,this paper established the standard of quality control in the anti-bronchial oral liquid,including ephedra herb,radix stemonae,celandine,qualitative identification,as well as content determination method to the main components of ingredients of ephedrine hydrochloride and celandine red alkali.Accelerated stability study results showed that the anti-bronchial oral liquid resistance stability is good.This paper studies new drug technology and quality research of the Kang zhi Oral Liquid to provide the scientific information,laid a good foundation for the later pharmacodynamic and safety study.