Association Between Psychological / Physicochemical Environment Factors And Reproductive Health

Background: Studies had shown that unhealthy psychological status,including stress,depression and anxiety were responsible for reproductive function in women,such as abnormal menstruation and prolonged time-to-pregnancy,which could finally reduce fertility.However,findings on the association between stress,depression or anxiety and female reproductive function were not consistent,and there was a lack of research in Chinese population,especially in preconception women,it was necessary to explore the relationship between mental problem and female reproductive function in a large prospective study with large sample and high quality.Objective: We aimd to understand the effect of pre-pregnancy psychological factors on the reproductive function in female and evaluate the effect of PFASs on the association between women’s mental health and irregular menstruation through a recruitment of women volunteers and their spouses who participated in free pre-pregnancy physical examinations in Shanghai.Method:1.This was a cross-sectional study in 1184 couples who tried to conceive to evaluate pre-pregnancy psychological status including stress,depression and anxiety symptoms and understand correlations of psychological status in the couple by a preconception cohort of the Shanghai birth cohort.2.This was a cross-sectional study in 1184 women volunteers who tried to conceive to evaluate the association between pre-pregnancy psychological factors including stress,depression and anxiety symptoms and different types of menstrual disorder by a preconception cohort of the Shanghai birth cohort.3.We conducted a prospective cohort study to evaluate the effects of stress,depression and anxiety symptoms on pregnancy rates in 1184 women volunteers who tried to conceive by the Shanghai birth cohort.4.This was a cross-sectional study in 1184 women volunteers who tried to conceive to evaluate an effect of PFASs on relationships between women’s sociopsychological environment and irregular menstruation by a preconception cohort of the Shanghai birth cohort.Result:1.The incidence of pre-pregnancy depression and anxiety symptoms were 13 %and 5 %,respectively.The psychological status of couples before pregnancy was not significantly positively correlated.2.Risk of premenstrual symptoms,dysmenorrhea,abnormal menstrual amount and irregular menstruation was increased by 5 %,3 %,10 % and 6 %,respectively for every one unit increase in women’s stress score before pregnancy.Compared with the lowest quartile,the risk of premenstrual syndrome and abnormal menstruation in the highest quartile of depression level increased significantly,and the adjusted OR value were 1.63(95% CI: 1.07-2.48)and 1.68(95% CI: 1.01-2.79).The risk of premenstrual syndrome,dysmenorrhea,abnormal menstrual amount and irregular menstruation was positively correlated with pre-pregnancy anxiety symptom,and had a tendency with an increase of anxiety level with a P value of less than 0.05.3.After adjustment for potential confounders,pregnant rate decreased by 2 % for every one unit increase of women’s stress score before pregnancy(a OR = 0.98,95% CI: 0.96 – 1.00).Compared with the lowest quartile,pregnant rate in the third quartile(a OR = 0.77,95% CI: 0.60 – 0.98)and the highest quartile(a OR= 0.77,95% CI: 0.60 – 0.99)of stress level decreased significantly.We didn’t find any significant effect of pre-pregnancy anxiety symptoms on pregnancy rate.4.Prepregnancy PFASs exposure could not change the relevance between social psychological environment and irregular menstruation.Conclusion: Social psychological environment,including stress,depression and anxiety symptoms was positively associated with menstrual disorder,and could reduce the fecundity in women,significantly.