Analysis Of Metabolic Pathways Of Homocysteine In Patients With Schizophrenia And Bipolar Disorder

ObjectIn this experiment,high-performance liquid chromatography-mass spectrometry(LC-MS / MS)was used to study the homocysteine content in plasma and the content of upstream and downstream metabolites in the metabolic pathways of patients with schizophrenia and bipolar disorder.The relationship between the differences in the content of the three metabolites and mental diseases has laid a preliminary foundation for the discovery of new diagnostic markers.MethodsThree groups of patients in the Shenyang City Mental Health Center Clinical Mass Spectrometry Center who conducted homocysteine metabolic pathway detection using high-performance liquid chromatography-mass spectrometry(LC-MS / MS)between June 2018 and June 2019 were analyzed.According to the data,group A is diagnosed with schizophrenia(222 cases),group B is with bipolar disorder(68 cases),and group C is a healthy population admitted to the same period(150 cases).Treatment,to compare the differences in the levels of substances related to homocysteine metabolic pathways(homocysteine Hcy,cysteine Cys and methionine Met)in patients with different mental disorders.ResultsThe Hcy levels of the schizophrenia group and the healthy control group were statistically different(P <0.001),and the average level of Cys in the schizophrenia group was significantly lower than that of the two-way emotional disorder group.The healthy control group had statistical differences(P <0.01).The average level of Met in the schizophrenia group and bipolar disorder group was higher than that in the healthy control group(P <0.001).No statistical significance(P> 0.05);the analysis of Hcy in blood of the experimental group showed that the proportion of Hcy levels in patients with schizophrenia was significantly higher than that in patients with bipolar disorder and healthy people;for undifferentiated Comparison of Hcy,Cys and Met levels in patients with schizophrenia and paranoid type showed that there was no statistical difference between the two groups in age and gender(P> 0.05)and serum Hcy,Cys,Met levels in patients with disease subtypes There was no statistical differencen comparison(P> 0.05).ConclusionBy comparing the levels of blood homocysteine metabolic pathways(Hcy,Cys,Met)in patients with schizophrenia and bipolar disorder,significant changes have occurred compared to healthy people.The increase of Hcy level and the decrease of Cys level in patients with schizophrenia is the most obvious,which may be used as a new biomarker for the diagnosis of this disease.