Short-term Efficacy Of Elemene Injection Combined With Concurrent Radiotherapy And Chemotherapy For Esophageal Cancer

Research objectives:The purpose of this study was to observe the adverse reactions and short-term efficacy of elemene injection combined with concurrent radiotherapy and chemotherapy in the treatment of esophageal cancer,and to explore the value of elemene injection in the treatment of esophageal cancer.Materials and methods:Sixty patients with esophageal cancer who met the admission criteria in Henan Cancer Hospital from January 2017 to January 2019 were randomly divided into two groups: the study group(concurrent radiotherapy and chemotherapy plus elemene injection)and the control group(concurrent radiotherapy and chemotherapy and radiotherapy),30 cases in each group.All patients were treated with intensity modulated radiotherapy(IMRT),once a day,five times a week,with a total dose of59.4 Gy/33 times.All patients received concurrent chemotherapy with TP regimen for2 cycles.The study group received intravenous infusion of elemene 0.4g daily for 3weeks from the beginning of radiotherapy.Before treatment,all patients were assessed including medical history,physical examination,electrocardiogram,blood biochemistry,liver and kidney function.Disease assessment projects include neck,chest enhancement CT,abdomen,pelvic color Doppler ultrasound,esophageal radiography,gastroscopy and pathology,radionuclide bone scan.Patients with dizziness,headache and other clinical manifestations,head CT or MRI examination.Clinical staging was performed according to the 2009 American Joint Committee onCancer(AJCC)staging criteria for esophageal cancer.One month after treatment,neck,chest enhancement CT,abdomen,pelvic color Doppler ultrasonography and esophageal radiography were performed,and the results were compared with those reported in the pre-treatment imaging journal.The efficacy was evaluated according to the Response Evaluation Criteria in Solid Tumors(RECIST)1.1.Results:1.There was no significant difference in age,KPS score,sex,lesion location and stage between the two groups(P > 0.05),They are comparable.2.Compared with the control group,the level of adverse reactions of the two groups was significantly different,including leukopenia(P < 0.05)and radiation esophagitis(P < 0.05).The adverse reactions of the study group were milder than those of the control group.There were no significant differences in thrombocytopenia(P > 0.05),gastrointestinal reaction(P > 0.05),and radiation pneumonia(P > 0.05).3.Comparing the incidence of adverse reactions between the two groups,the incidence of leukopenia(P < 0.05)and radiation esophagitis(P < 0.05)had statistical difference.There were no significant differences in the incidence of thrombocytopenia(P > 0.05),gastrointestinal reaction(P > 0.05),and radiation pneumonia(P > 0.05).4.Comparing the short-term curative effect between the two groups,the difference of effective rate(P < 0.05)has statistical significance.Conclusion:1.Elemene injection in concurrent radiotherapy and chemotherapy of esophageal cancer can reduce the occurrence of leukopenia and adverse reactions of radiation esophagitis,and reduce the degree of injury.2.Other adverse reactions(such as gastrointestinal reactions,thrombocytopenia,radiation pneumonia)occurred in the course of treatment and the degree of improvement was not obvious.3.Elemene injection can improve the short-term efficacy of concurrent radiotherapy and chemotherapy for esophageal cancer.