| Objective:Through the clinical research on the treatment of Idiopathic membranous nephropathy(IMN)with spleen and kidney qi deficiency and dampness-heat stasis syndrome by Yiqihuashitongluo decoction,the clinical efficacy,safety and scientificity of the treatment of IMN are explored To explore a new plan and new ideas for the treatment of IMN with integrated Chinese and Western medicine.Methods:Sixty patients with IMN that met the inclusion criteria were screened and randomly divided into the test group and the control group by SAS statistical software,according to a 1: 1 ratio,30 cases in each group.The control group combined with valsartan soft capsules(daiwen)(1 capsule once,once a day,orally)on the basis of general treatment;the experimental group added Yiqihuashitongluo decoction on the basis of the treatment of the control group.Take 12 weeks as a course of treatment.Observe and record the clinical symptoms,signs,plasma albumin(ALB),24-hour urine protein(24h-UTP),triglyceride(TG),total cholesterol(TCHO),antiphospholipidase A2 receptors before and after medication Antibodies(anti-Pl A2 R antibodies),coagulation four + D2 aggregates,renal function,glomerular filtration rate(e GFR)and other efficacy indicators and safety indicators,and quantitative scores of TCM syndromes,through statistical analysis,To discuss the evaluation of the clinical efficacy and safety of Yiqi Huashi Tang in the treatment of IMN.Results:A total of 60 patients were included in this study,30 in the control group and30 in the experimental group.One of the patients in the control group was excluded during the test.In total,59 patients were collected with complete clinical data,29 in the control group and 30 in the experimental group.The comparison of various indicators before and after treatment leads to the following conclusions:(1)The efficacy of TCM syndromes:After treatment,the control group has an effective rate of 75.86% and the experimental group has an effective rate of 83.33%.The difference in statistical treatment between the two groups after treatment is significant(P<0.05),indicating that the test group is superior to the control group in improving TCM syndromes;(2)24-hour urine protein quantification:after treatment,the 24-hour urine protein quantification of both groups is lower than before,the control group and the test group are treated 4 After week comparison,there was no statistical difference between the two groups(P=0.345>0.05),indicating that there was no significant difference between the two groups.The control group and the experimental group were treated for 8 weeks,and after the end of treatment,the experimental group was lower than the control group(all P<0.05),the statistical processing difference is significant,indicating that the treatment effect of the experimental group is better than the control group in the long run;(3)serum albumin: after treatment,the serum albumin in both groups is higher than before,the two groups are treated The statistical difference was statistically significant(P<0.05),indicating that the test group was better than the control group in improving serum albumin;(4)Blood lipids:after treatment,the cholesterol and triglyceride levels of the two groups decreased.After treatment Compared with statistical processing,the difference was significant(P<0.05),indicating that the experimental group was better than the control group in improving blood lipids;(5)Anti-Pl A2 R antibody:after treatment,the anti-Pl A2 R antibody in both groups decreased compared with before treatment.The difference between the two groups after treatment was statistically significant(P<0.05),indicating that the test group was superior to the control group in reducing anti-Pl A2 R antibodies;(6)Renal function:after treatment,both groups of blood creatinine and urea nitrogen The glomerular filtration rate was higher than before and the renal function was improved to a certain extent.There was no statistically significant difference between the two groups after treatment(P>0.05),indicating that the two groups improved renal function Similar effects;(7)Comprehensive clinical efficacy:after treatment,the total effective rate in the test group was 90%,and the total effective rate in the control group was 79.31%.The difference in statistical processing between the two groups after treatment was significant(P<0.05),It shows that the experimental group has more obvious advantages in improving the comprehensive clinical efficacy.Conclusions:1.Yiqi Huashi Tongluo Decoction has the effect of enhancing the efficacy of spleen and kidney qi deficiency and damp heat stasis syndrome of idiopathic membrane nephropathy(IMN),it is worth further research and promotion.2.Yiqi Huashi Tongluo Decoction is mainly for strengthening the spleen,tonifying the kidney,clearing heat and dampness,promoting blood circulation and removing blood stasis.It can reduce clinical symptoms such as edema and fatigue,and can also reduce urine protein,serum albumin,blood lipid,anticoagulation,and protection.Renal function,delay the progression of chronic kidney disease,and improve the quality of life of patients. |
