The Influence On The Microvessel Function Of Bushen Hemai Prescription Granules In Grade 1 Isolated Systolic Hypertension

Objective:To explore the influence on the microvessel function of Bushen Hemai Prescription granules in grade 1 isolated systolic hypertension.Methods:Designed as a prospective,completely randomized,positive drug control,double-blind double-simulation single-center clinical trial.The clinical blood pressure,urine albumin-creatinine ratio(UACR)and routine ophthalmoscopy changes were used as the outcome indicators.After 24 weeks of treatment,To evaluate the efficacy and safety of Bushen Hemai Prescription granules+Perindopril tablet placebo(test group n=29)and Perindopril tablets+Bushen Hemai Prescription granules placebo(control group n=31).Results:The baseline demographic a nd clinical characteristics of the two groups,and the parameters of the office blood pressure were comparable before treatment(all P<0.05);There was no significant difference in the blood pressure parameters of the office between the groups at 12 weeks of treatment(P<0.05);Compared with the control group,the systolic and pulse pressures of the experimental group decreased further by 4-6 mmHg after 24 weeks of treatment,and the difference was significant(P<0.05),The UACR level was significantly reduced(P<0.05),and retinal arteriosclerosis was significantly improved(P<0.05).The difference is mainly due to the improvement of grade Ⅲ to grade Ⅱ,and the changes of arteriolar spasm and light reflection of blood vessel wall are also better than those of the control group(P<0.05).Conclusion:In patients with grade 1 isolated systolic hypertension and kidney-qi deficiency syndrome.Compared with standard application of perindopril tablets,BushenHemai Prescription granules may further reduce systolic and pulse pressures by reducing arterial stiffness.Significantly improve the microvascular function markers,which may produce the dual protection of large artery elastic function and microvascular function.