Feasibility Analysis Of Early Antihypertensive Therapy For Patients With Acute Ischemic Stroke

Objective To analyze the feasibility of early antihypertensive therapy in patients with acute ischemic stroke(AIS).Methods A total of 120 patients with AIS who were admitted to the hospital between August2017 and January 2018 were enrolled in the study.They were divided into group A,group B and group C by the random number table method,40 cases in each group.The three groups were treated with antihypertensive drugs at 3,5 and 7 days after stroke,respectively.The changes in systolic blood pressure(SBP)and diastolic blood pressure(DBP),neurological function [National Institutes of Health Stroke Scale(NIHSS),modified Rankin scale(MRS)],incidence rates of ischemic stroke,recurrence rates,mortality rates and incidence rates of disability in the three groups were analyzed.Results SBP and DBP of all groups were decreased after 24 h of treatment.SBP and DBP of group A were lower than those of group B and group C after 24 h of treatment.The decreased values of SBP and DBP in group A were larger than those in group B and group C within 24 h after treatment(P<0.05).There was no significant difference in SBP or DBP after 24 h of treatment or their decreased values within 24 h after treatment between group B and group C(P>0.05).NIHSS and MRS scores in group B and group C were lower than those in group A at 1 month and 3 months after treatment(P<0.05),with significant differences between group B and group C(P<0.05).There were significant differences in difference values of NIHSS and MRS scores in each group before treatment and at 1 month and 3 months after treatment(P<0.05).Besides,the difference values of NIHSS and MRS scores were the highest in group B(P<0.05).There was no significant difference in the incidence rate of ischemic stroke,recurrence rate,mortality rate or incidence rate of disability among the three groups(P>0.05).Conclusion Early antihypertensive therapy can help improve blood pressure levels of patients with AIS.The antihypertensive therapy which is given at 3 days after stroke works the fastest but it is not conducive to the recovery of neurological function,without obvious effects in reducing the risk of recent ischemic stroke,recurrence rate,mortality rate or incidence rate.The effect of antihypertensive therapy given at 5 days after stroke is satisfying and the neurological function recovers relatively better.It can be used as the best time for early antihypertensive therapy.