Analysis Of Related Risk Fators Of Endometrial Cancer In Postmenopausal Women With Uterine Cavity Effusion

Objective To analyze related risk factors of endometrisl cancer in postmenopausal women with uterine cavity effusion.Methods 150 patients with effusions in their uterine cavity after menopause who received treatment at the gynecology outpatient clinic of First Affiliated Hospital of Hebei North University during the period from January 2019 to December 2019 were randomly included in this research,and their age,age of menopause,volume of effusions,endometrial thickness,signal of blood flow,complications including vaginal bleeding,hypertension and diabetes,postmenopausal use of estrogenic drugs,obesity(BMI≥28kg/m~2)and other clinical data collected.All patients received hysteroscopy and biopsy.By the final gold standard of histopathologic results,150 patients were divided into the observation group of postmenopausal effusions in uterine cavity complicated with endometrial cancer(25 cases),and the control group of postmenopausal effusions complicated with benign lesions(125 cases).Clinical characteristics and related risk factors of two groups were then analyzed with statistical methods,with P<0.05 as the standard of statistical significance,P<0.01 indicates high statistical significance or significant differences.Results Differences between the two groups in age of menopause,postmenopausal use of estrogen drugs,and obesity were not statistically significant(t=1.034,x~2=0.000,1.918,P>0.05 for all);in terms of years since menopause,volume of uterine cavity effusion,endometrial thickness,blood flow signals,complication of vaginal bleeding,and complication of hypertension and(or)diabetes,the observation group was larger than the control group,the differences being statistically significant(t=3.161,u=6.301,t=8.748,x~2=60.732、4.075、4.567,P<0.05 for all).According to results of univariate and multivariate logistic regression analysis,independent risk factors of endometrisl cancer in postmenopausal women with uterine cavity effusion are years since menopause,volume of uterine cavity effusion,endometrial thickness,blood flow signals,complication of vaginal bleeding,and complication of hypertension and(or)diabetes(P<0.05 for all).Among these independent risk factors depending on the OR value,endometrial thickness is associated with the highest risk of endometrial cancer in menopausal women with endometrial cavity fluid,followed by combined hypertension and/or diabetes,blood flow signals,amount of endometrial cavity fluid,combined vaginal bleeding,and length of time after menopause.Conclusion 1.Endometrial cavity fluid in menopausal women may indicate endometrial cancer,and the risk factors mainly include endometrial thickness,combined hypertension and/or diabetes,presence of blood flow signals,amount of endometrial cavity fluid,vaginal bleeding,and length of time after menopause.2.Among these independent risk factors,endometrial thickness is associated with the highest risk of endometrial cancer in menopausal women with endometrial cavity fluid,followed by combined hypertension and/or diabetes,blood flow signals,amount of endometrial cavity fluid,combined vaginal bleeding,and length of time after menopause.3.If it is found that there is intrauterine effusion after menopause and ultrasound indicates endometrial thickening and blood flow signals,much attention must be paid to the occurrence of endometrial cancer once vaginal bleeding symptoms occur and patients have such chronic diseases as hypertension or diabetes mellitus.4.Hysteroscopic results highly agree with histopathologic results.Timely hysteroscopy for female patients with effusions in uterine cavity after menopause helps with early discovery of endometrial lesions.