Clinical Observation Of Bazhen Decoction Combined With Dopasazide Tablets In The Treatment Of Parkinson Disease With Qi And Blood Deficiency

Purpose:To investigate the effect and safety of Clinical Observation of Bazhen decoction combined with dopasazide tablets in the treatment of Parkinson disease with Qi and blood deficiency in the treatment of Parkinson’s disease with Qi and blood deficiency type by exploring the changes of TCM syndrome score scale,Chinese version of Unified Parkinson’s score scale MDS-UPDRS(Ⅱ,Ⅲ),non-motor symptom global assessment scale and Parkinson’s disease quality of life scale(PDQ-39)before and after treatment,so as to understand the efficacy and safety to provides a useful reference for the future promotion and application.Methods:1.Medical Records:30 cases of Parkinson’s disease selected from Xiangyang Hospital of Traditional Chinese Medecine with Qi and blood deficiency diagnosed and treated in the outpatient department of encephalopathy from December 2018 to November 2019 and randomly divided into control group and treatment group with 15 cases in each group.Through the comparison of the general data of the two groups,the difference was not statistically significant(P>0.05).2.Treatment:the control group was given Madopar treatment,and the first time was 62.5mg,4 times a day,interval 6 hours,1 weeks later,adjusted to 125mg,3 times one day,and took it every 8 hours,then maintained the original dose or increased to the appropriate range accordingly.On this foundation,the treatment group togetherwith oral Chinese medicine decoction(Radix Paeoniae Alba 30g,Glycyrrhiza 10g,Codonopsis pilosula 30g,Poria cocos 20g,Atractylodes macrocephala 30g,vinegar turtle carapace 30g,prepared ground 20g,Psoralea 10g,Eucommia ulmoides 10g,Amomum villosum 10g,Achyranthes bidentata 10g,Angelica Sinensis 10g,and then add or subtract according to the symptoms.After boiling over high heat for 0.5h,decoct 400ml,take 200ml in the morning and evening,200ml each time.)The course of treatment was 3 months.The efficacy and safety were evaluated after 3 months,and followed up 2 months after the end of the study.During the period,the patients were exhorted to regulate their emotions,balance nutrition,moderate exercise and bedtime routine.3.Outcome measures:①efficacy evaluation:TCM syndrome score scale,Chinese version of Unified Parkinson’s score scale MDS-UPDRS(Ⅱ,Ⅲ),Parkinson’s disease quality of life scale(PDQ-39);②safety evaluation:blood,urine and stool routine,liver function,electrocardiogram.4.Statistical processing:Spss22.0 statistical software was used for statistical processing.Repeated measurement analysis of variance was used if the measurement data were in accordance with normal distribution and the variance was homogeneous;chi square test was used for non rank data in count data and the rank sum test was used for grade data;T test was used for comparison between the two groups;all statistical results were judged according to p value:P<0.05 was statistical significance,P>0.05 was not statistical significance.Results:①According to statistical analysis and comparison:there was no significant difference in age,gender,course of disease and H-Y grade between the two groups(P>0.05).②After treatment,the TCM symptom score,MDS-UPDRS(Ⅱ,Ⅲ)score,non-motor symptom global assessment scale and PDQ-39 score of the treatment group were significantly lower than those of the control group,the difference was statistically significant(P<0.05).③Evaluation of therapeutic effect:the TCM symptom scores before and after treatment were evaluated by nimodipine method,the total effective rate of the treatment group was 90.00%,and that of the control group was 66.67%,indicating a significant statistical difference(P<0.05).④Before and after treatment,the two groups of patients with blood,urine,stool routine,liver function,electrocardiogram etc did not occur abnormal,which meant it has a certain degree of safety.Conclusion:Bazhen decoction combined with dopasazide tablets in the treatment of Parkinson’s disease with Qi and blood deficiency can significantly ameliorate their clinical symptoms,which is better than that of Madopar.At the same time,it can also avoid the side effects caused by the massive application of Madopar with high safety and no adverse phenomenon in the whole research process,so it is worthy of clinical promotion and application.