| PurposeIn this study,L-carnitine combined with creatine phosphate sodium in the treatment of myocardial damage caused by Mycoplasma pneumoniae infection was used to observe the treatment effect,and to explore the safety and effectiveness of the treatment scheme,so as to provide more optimized treatment scheme for clinicians in the treatment of myocardial damage caused by Mycoplasma pneumoniae infection.Methods74 patients aged from 2 to 14 years with myocardial damage caused by Mycoplasma pneumoniae infection in Hospital from January 2019 to December 2020 were randomly divided into two groups:(1)control group(group A)with 36 cases;(2)experimental group(group B)with 38 cases.Group A was given azithromycin for injection 10 mg /(kg.D),once a day,intravenous drip anti infection treatment,the maximum daily dose was 0.5g;given creatine phosphate sodium for injection 1g / D,once a day,intravenous drip nutritional myocardial treatment;at the same time,given antipyretic cough and other symptomatic support treatment.Group B was given levocarnitine 50 mg /(kg.D),twice daily,with the maximum dose of 3 g per day.The clinical symptoms(such as fever,cough,chest tightness,shortness of breath,etc.)were recorded at the time of admission,and fasting venous blood was collected for examination on the second day of hospital and the seventh day after treatment.The detection items included blood routine,CRP,myocardial enzyme spectrum(AST,CK,CK-MB,HBDH,LDH),troponin I and Mycoplasma pneumoniae antibody.At the same time,chest X-ray,ECG and color Doppler ultrasound examination were improved.At the same time,the clinical symptoms of the two groups were recorded.Result1.Comparison of clinical manifestations between group A and group B:There was no significant difference in the time and number of cases of fever,cough and myocardial damage symptoms between the two groups before admission(P > 0.05).After treatment,there was no significant difference in the time of fever abatement and cough relief between the two groups(P > 0.05),but the disappearance time of myocardial damage symptoms in group B was shorter than that in group A(P < 0.05).2.Comparison of curative effect between group A and group B:In group A,14 cases were cured(39%),19 cases were improved(53%),and 3 cases were invalid(8%);in group B,27 cases were cured(71%),10 cases were improved(26%),and 1case was invalid(3%).The number of cured patients in group B was significantly more than that in group A.There was significant difference in the cure rate between the two groups(P < 0.05),but there was no significant difference in the total effective rate(P > 0.05).3.Comparison of inflammatory indexes between group A and group B:Before treatment,there was no significant difference in WBC and CRP between the two groups(P > 0.05).After treatment,the above indexes were improved(P < 0.05),but there was no significant difference in WBC and CRP between the two groups(P >0.05).4.Comparison of myocardial enzymes between group A and group B:Before treatment,there was no significant difference in AST,CK,CK-MB,HBDH and LDH between the two groups(P > 0.05).After treatment,the above indexes were improved compared with before(P < 0.05).There was no significant difference in AST and HBDH between the two groups(P > 0.05),but there was significant difference in CK,CK-MB and LDH between the two groups(P < 0.05),and group B was significantly lower than group A.5.Comparison of troponin I between group A and group B:Before treatment,there was no significant difference in troponin I between the two groups(P > 0.05).After treatment,in group A,10 cases turned negative(50.0%),7 cases improved(35.0%),3 cases ineffective(15.0%),in group B,18 cases turned negative(81.8%),3cases improved(13.6%),1 case ineffective(4.6%);there was significant difference in the negative conversion rate between the two groups(P < 0.05).6.Comparison of ECG between group A and group B:Before treatment,there was no significant difference in ECG between the two groups(P > 0.05).After treatment,the negative conversion rate of group A was 78.9%,and that of group B was 100%;there was significant difference in the negative conversion rate between the two groups(P < 0.05).7.Comparison of chest X-ray films between group A and group B : Before treatment,there was no significant difference in chest X-ray between the two groups(P > 0.05).After treatment,in group A,20 cases were cured(55.6%),13 cases were improved(36.1%),3 cases were invalid(8.3%),and the total effective rate was 91.7%;in group B,24 cases were cured(63.1%),12 cases were improved(31.6%),1 case was invalid(5.3%),and the total effective rate was 94.7%;After treatment,the two groups were better than before treatment,but there was no significant difference in the cure rate and total effective rate between the two groups(P > 0.05).ConclusionIn the treatment of myocardial damage caused by Mycoplasma pneumoniae infection,on the basis of conventional symptomatic support treatment and anti-infection treatment,L-carnitine combined with creatine phosphate sodium can more effectively alleviate the clinical symptoms of myocardial damage,more effectively reduce myocardial enzyme spectrum and troponin I,more effectively promote the recovery of ECG,the treatment effect is better,and the combination of the two drugs will not increase the incidence of adverse events,which is worthy of clinical promotion and application. |
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