Phase Angle And Its Influencing Factors In Patients With Cancer

Objective:To explore the difference of phase angle under different clinical features in common malignant tumors,and to explore the influencing factors of phase angle.Methods:Using retrospective analysis,to collect and sort out the data of common malignant tumor patients’ nutrition status and clinical outcomes(INSCOC)from January 2017 to December 2019 in the cancer center of the first hospital of Jilin University.Single-factor single-factor analysis of variance was used to analyze whether there were statistically significant differences in the phase angles of different malignant tumors.According to PG-SGA score,PG-SGA was classified as well nourished(PG-SGA a 0～1),suspected or moderate malnutrition(PG-SGA B 2～8),and severe malnutrition(PG-SGA C ≥ 9).To compare the difference of clinical indexes between high and low phase angle groups,Pearson correlation analysis was carried out for laboratory indexes and anthropometry indexes,and the correlative indexes were further included in linear regression analysis,so as to clarify the influence factors of phase angle.Results:1.The mean phase angle(5.31 ± 0.88)° in male patients was higher than that(4.17 ± 0.85)° in female patients.The mean phase angle(5.24 ± 0.87)° in patients younger than 65 years was higher than that(4.72 ± 0.92)in patients older than 65 years.The difference of phase angle in sex and age has statistical significance.2.Different phase Angle average of the patients with primary tumor site,tumor for the average phase Angle in the respiratory system(5.18 ±0.92)°,digestive system tumors(5.00±0.91)°,mammary gland malignant tumors(4.76±0.81)°,urogenital system tumor(4.83 ±0.86)°,head and neck cancer(5.31 ± 1.16)°,blood system for(5.40± 1.04)°,other is(5.07 ±0.98)°,and different phase Angle difference between the primary tumor site there is statistical significance(P<0.001).The mean phase Angle of the PG-SGA score group A,B and C was(5.24±0.85)°,(5.06±0.96)° and(4.69±0.87)°,respectively.The phase Angle of the patients with deteriorating nutritional status was decreased with statistical significance.3.The differences of clinical features,laboratory indexes and body measurements between different groups with different phase angles were compared.There were significant differences in phase angles between age 65,sex,PG-SGA and tumor stage(P<0.05),however,there was no significant difference in body weight change after 30 days.Albumin in low PA group[(35.27±5.34)g/L vs(39.10±10.44)g/L,P<0.05],triglyceride[(1.42±0.72)mmol/L vs(1.58±1.62)mmol/L,P<0.05],hemoglobin[(113.98±23.88)g/L vs(130.14±23.63)g/L,P<0.05]was lower than the control group,while CRP and PLR were higher than the control group,with statistical significance.There were no statistically significant differences in pre-albumin,urea nitrogen,cholesterol and NLR between the two groups.4.Pearson correlation analysis was performed on laboratory indicators and physical measurement related indicators.The results indicated that the phase Angle was positively correlated with albumin(r=0.162),triglyceride(r=0.077),hemoglobin(r=0.342),BMI(r=0.303),FFMI(r=0.355),non-beneficial hand strength(r=0.391)and MAMC(r=0.364)(P<0.05).It was negatively correlated with CRP(r=-0.145)and PLR(r=-0.117),but had no correlation with prealbumin,urea nitrogen,cholesterol and NLR.Linear regression analysis indicated that albumin,C-reactive protein,hemoglobin,FFMI,non-dominant hand strength and upper arm muscle circumference were predictors of phase Angle(P<0.05).Conclusion:1.The phase angle of patients with malignant tumor is different in different tumor,age and nutritional status.The phase angle was higher in men,patients younger than 65 years of age and in good nutritional condition.2.Phase angle is positively correlated with the nutritional indexes of tumor patients,and negatively correlated with the inflammatory indexes.Phase angle can be used as a good indicator to evaluate the overall health level of malignant tumor patients.3.Albumin,C-reactive protein,hemoglobin,FFMI,non-dominant hand grip strength and upper arm muscle circumference were the influencing factors of phase angle.