Clinical Analysis Of 103 Cases Of Non-severe Aplastic Anemia

Objective: This research through to the jilin province people’s hospital of 103 cases of patients with severe aplastic anemia,were retrospectively analyzed,analysis summary this group of patients with severe aplastic anemia clinical characteristic,treatment methods,efficacy and prognosis,find NSAA treatment opportunity,effective treatment,may affect the curative effect and adverse drug reactions,To improve the early diagnosis and treatment of this disease to provide more clinical basis.METHODS: The case data of all 103 inpatients with non-severe aplastic anemia who were newly diagnosed from October 2014 to October 2019 were collected by case retrospective analysis,including age of onset,gender,medication history,occupational exposure history,family history,onset to treatment time,medical history after admission,blood routine examination,bone marrow morphology,bone marrow biopsy,CD55,CD59 and other tests at the time of initial diagnosis,blood routine examination,liver and kidney function examination results before and after Cs A treatment,efficacy and prognosis.To sex,age,before the platelet count,hemoglobin before treatment,treatment before the neutrophil count,blood transfusion,infection and treatment time and different treatments included in the analysis and application of SPSS2.0 for data analysis,the curative effect on the patients,the disease outcome and influence factors were analyzed,and P < 0.05 think the difference was statistically significant.Results:1.General situation: The gender difference between males and females in this study is not large,and males are slightly higher than females;the age of onset is 15-79 years old,the median age of onset is 48 years old,and the high-incidence age groups are 21-30 years old and 60 years old.Group of patients over the age of;occupational distribution: farmers account for the highest proportion,and the rural population has a high incidence.2.Clinical manifestations(first symptom): The first symptom of patients with non-severe aplastic anemia is simple anemia,which may be combined with bleeding,and infection is rare.3.Routine blood examination:Peripheral blood cytopenia is mainly the three-line reduction;there is no statistically significant difference in hemoglobin count,platelet count,absolute value of neutrophils,and reticulocyte count in patients with onset age ≥60years old and <60 years old group.4.Bone marrow examination: the main bone marrow morphology test is hypoplasia,some are hyperplasia,and bone marrow biopsy shows hypoplasia.Most of the diagnosis of NSAA requires another sternal bone biopsy to confirm the diagnosis.5.Analysis of curative effect and prognosis of different onset to treatment time:The difference in NR rate,effective rate,progression rate,and maintenance rate of NSAA in the onset to treatment time ≤ 6 months group,6 months to 3 years group,and> 3years group was statistically significant(all P values <0.05).The effective rate of the ≤6months group was significantly higher than that of the 6 months to 3 years group and the >3 years group;the NR rate and the progression rate of the ≤6 months group were lower than the 6 months to 3 years group and the >3 year group;The maintenance rate of NSAA in the ≤6 months group and the 6 months to 3 years group was higher than that in the >3 years group.There was no statistical difference in CR rate,PR rate,and mortality rate among the three groups.6.Analysis of the efficacy and prognosis of the blood transfusion-dependent NSAA group and the non-transfusion-dependent NSAA group:There was nostatistically significant difference in CR rate,PR rate,and NR rate between the two groups.The progress rate and the maintenance rate of NSAA in the two groups were statistically significant(P<0.05).The progression rate of transfusion-dependent NSAA was higher than that of non-transfusion-dependent NSAA,and the rate of maintenance NSAA was lower than that of transfusion-dependent NSAA group.There was no significant statistical difference between the two groups in CR rate,PR rate,NR rate and mortality.7.Alysis of the efficacy of different treatment options shows:There were no statistically significant differences in CR rate,PR rate,NR rate,and total effective rate of treatment programs in groups A,B,and C for 6 months and 12 months.8.Related factors affecting efficacy:The time from onset to treatment,platelet count before treatment,and neutrophil count before treatment were significantly correlated with the efficacy(all P values <0.05).The time from onset to treatment is less than 6 months,PLT before treatment>20×109/L,and ANC>1×109/L before treatment are related factors for good curative effect.Age of onset,gender,hemoglobin before treatment,and different treatment options have no significant correlation with the efficacy.Conclusion:1.The age of onset of aplastic anemia is mostly young and middle-aged,and there is no obvious difference in the sex ratio between men and women.2.NSAA’s early immune intervention treatment(from onset to treatment interval ≤ 6months)can improve the effective rate of treatment and delay the progression of the disease.3.Compared with the non-transfusion-dependent NSAA,the blood transfusion-dependent NSAA has a higher rate of disease progression,and there is no significant difference in the efficacy between the two groups.4.The factors influencing clinical efficacy included the time from onset to treatment,platelet count before treatment and neutrophils count before treatment.