A Controlled Study Of The Effects Of Depressive Symptoms On The Cognitive Function Of Patients With Schizophrenia

Objective:To explore the difference of clinical symptoms and cognitive function of schizophrenia patients with or without depressive symptoms,and the influence of depressive symptoms improvement on cognitive function,analyze the correlation between CDSS-C score and RBANS score,and further understand the relationship between depressive symptoms and cognitive function of schizophrenia patients.Methods:Selected to be hospitalized at Qingdao Mental Health Center,Shandong Province from June 2019 to June 2020,in line with the diagnostic criteria of schizophrenia in the fifth edition of the American Diagnostic and Statistical Manual of Mental Disorders(DSM-V),60 patients with schizophrenia between the ages of 18 and 60 were evaluated according to the Chinese version of the Calgary Schizophrenia Depression Scale(CDSS-C),and were classified as not accompanied by depressive symptoms(CDSS-C<6 points)and with depressive symptoms(CDSS-C ≥ 6 points),30 cases in each group.The group without depressive symptoms was treated with olanzapine,and the group with depressive symptoms was treated with olanzapine combined with sertraline.Patients in both groups were treated for 8 weeks.Before treatment,compare the Chinese Version of Calgary Depression Scale for Schizophrenia(CDSS-C)score,Positive and Negative Symptom Scale(PANSS)score,and Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)scores of the two groups of patients with schizophrenia with and without depressive symptoms,and compare the CDSS-C score,PANSS score,and RBANS score of the two groups again after treatment.At the same time,the CDSS-C score,PANSS score,RBANS score of each group before and after treatment were compared,as well as the score difference between the two groups before and after treatment,and the correlation between depressive symptoms and cognitive function of the group with depressive symptoms before treatment was analyzed.Results:1.Before treatment,the CDSS-C score and PANSS negative scale score of the depression group were higher than those of the non-depression group(P<0.05),the PANSS positive scale score and the total score of RBANS and immediate memory,visual span,speech function,attention The scores of dimensionality and delayed memory were lower than those without depression(P<0.05).2.Before treatment,the CDSS-C score of the depression group was negatively correlated with the total score of RBANS and the dimensions of immediate memory,visual span,speech function,attention and delayed memory(P<0.05).3.After treatment,the total score of CDSS-C and PANSS negative scale in the depression group were lower than before treatment(P <0.05),and the score of RBANS vision span was higher than before treatment(P < 0.05);and the total PANSS of the two groups Scores,positive scale scores,and general psychopathological scores were all lower than those before treatment.The total scores of RBANS and the scores of immediate memory,attention and delayed memory in the two groups were all higher than those before treatment(P<0.05).4.After treatment,the difference between the scores of CDSS-C,PANSS and RBANS in the group with depression and before treatment was higher than that in the group without depression(P<0.05).Conclusion:This study found that the cognitive impairment of schizophrenic patients with depressive symptoms is more serious than that of patients without depressive symptoms,and the score of depressive symptoms is positively correlated with the severity of cognitive impairment.Treating depressive symptoms of schizophrenia patients has a certain beneficial effect on improving cognitive function.It is further proved that depressive symptoms may play a role in the mechanism of cognitive impairment in patients with schizophrenia,which provides a new direction for guiding us to treat the cognitive function of patients with schizophrenia.