Treatment Of Insomnia In Parkinson’s Disease With Huoxue Lishui Anshen Fang Clinical Efficacy Study

Objective: To observe the clinical efficacy and safety of Huoxue Lishui Anshen Decoction in the treatment of insomnia patients with Parkinson’s disease.Methods: From 01 December 2018 to 31 December 2020,patients with insomnia from Parkinson’s disease who were admitted to the Department of Encephalopathy of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,In 60 cases,They were divided into control group and treatment group,30 cases each,Patients in the control group were given routine treatment of Parkinson’s disease and symptomatic treatment with other basic diseases after entering clinical trials,Combined with alprazolam tablets,Use 0.4～0.8 mg/ times,1 bedtime per night;On the basis of routine western medicine treatment,the treatment group was treated with Huoxue Lishui Anshen recipe,One dose a day,Flush water to 400 ml,Morning,after dinner,two warm clothes,The course of treatment was 1month.The unified Parkinson’s disease rating scale III(UPDRS-III)and Parkinson’s disease sleep scale(Parkinson’s Disease Sleep Scale,)were performed before and after 1 month of treatment PDSS,and ESS,Pittsburgh Sleep Quality Index(Pittsburgh sleep quality index,)Scale PSQI,Standard Scale for the Evaluation of TCM Efficacy TESS),To observe the difference between the two groups,And security assessments,Using statistics to compare the two groups of data comprehensive analysis,To evaluate the clinical efficacy and safety of Huoxue Lishui Anshen recipe in the treatment of insomnia patients with Parkinson’s disease.Results:1.Effect of TCM Syndrome: After treatment,the total effective rate of the treatment group was 83.33% and the control group was 50%.There was significant difference between the two groups(P<0.05).2.PDSS score: The PDSS score of the two groups was higher than that before treatment(P<0.05),and the score of the treatment group was significantly higher than that of the control group(P<0.05).3.ESS scores: the ESS score of the two groups was lower than that before treatment(P<0.05),and the score of the two groups after treatment was significantly lower than that of the control group(P<0.05).4.PSQI score: intra-group comparison: the total score of PSQI after treatment was significantly lower than that of PS-QI before treatment,and the total score of treatment group was significantly lower than that of control group(P<0.05).The scores of sleep quality,sleep time,sleep time,sleep efficiency and daytime dysfunction in the two groups decreased after treatment(P<0.05),compared with the treatment group(P<0.05),compared with the control group(P<0.05),the score of sleep disorder in the two groups decreased after treatment(P<0.05),and the difference between the treatment group and the control group was not significant(PP<P<0)compared with the two groups The score of hypnotic drugs in the two groups was lower than that before treatment(P<0.05),and there was no significant change between the control group and the control group(PP<P<0.05).The score of the treatment group was significantly lower than that of the control group(P<0.05).5.UPDRS-III score:The UPDRS-III scores of the two groups were improved in different degrees after treatment(P<0.05),and the improvement of the treatment group was better than that of the control group(P<0.05).6.TCM symptom score: after treatment group contrast: treatment group TCM symptom score is obviously lower than before treatment;control group TCM symptom score is obviously lower than before treatment(P<0.05).After treatment,the TCM symptom score of the treatment group decreased significantly compared with the control group(P<0.05).7.Safety evaluation: the overall safety of the two groups was better and the incidence of adverse reactions was low.Conclusion: Huoxue Lishui Anshen Decotion can obviously improve the PDSS、ESS、PSQI、UPDRS-III and TCM symptom score of insomnia patients with Parkinson’s disease with water stasis and mutual junction,improve the sleep quality of patients obviously,the clinical effect is accurate,the safety is high,and the side effects are less.