Clinical Study Of Qianyangyuyin Granules Early Intervention To Delay The White Matter Lesions In Patients With Hypertensive Cognitive Impairment

Objective:By analyzing the relationship between the scores of the modified Scheltens scale,clinical symptoms and neuropsychological scale,and further using the modified Scheltens scale to evaluate the progression of white matter lesions.longitudinal evaluation of Qianyangyuyin granules for cerebral white matter lesions associated with high blood pressure caused by the effect of cognitive impairment,and evaluate its drug safety,aims at providing a Qianyangyuyin granules provide a basis for cognitive impairment associated with high blood pressure,and discuss the related mechanism.Method:A total of 40 patients with hypertension and mild cognitive impairment who met the inclusion criteria and were indicated to have white matter degeneration by brain MRI examination were selected.They were randomly divided into control group and treatment group using random number table to generate random numbers.The control group was given conventional western medicine for their basic diseases,such as blood pressure control,lipid regulation and plaque stabilization.In the treatment group,Qianyangyuyin granules were added to the basic treatment,for 24 weeks.The changes of neuropsychological scale scores and white matter visual scale scores before and after treatment were observed in the two groups.The adverse conditions during treatment were observed to evaluate the efficacy and safety of Qianyangyuyin granules.At the same time,the correlation between the scores of the modified Scheltens scale and the scores of the clinical symptoms and neuropsychological scale was compared to analyze the correlation.Results:There was no statistical significance in gender,age,history of hypertension and educational level between the two groups(P>0.05).After treatment,there were statistically significant differences in MMES,MOCA,VADAS-COG and modified Scheltens scores between the treatment group and the control group(P<0.05).There was no statistical significance in ADL and CDR scores(P>0.05).The relationship between the modified Scheltens scale,history of hypertension and neuropsychological scale was analyzed.It was found that there was a positive correlation between the modified Scheltens scale and history of hypertension,and a negative correlation between the modified Scheltens scale and MMSE and MOCA,with statistical significance(P<0.05).In terms of safety,there were no statistical differences in blood,urine,feces routine,liver,kidney function,ECG and other indexes before and after treatment between the two groups,and no adverse drug reactions occurred.Conclusion:Qianyangyuyin granules combined with conventional western medicine basic treatment can effectively intervene in the cognitive impairment of patients with hypertension,possibly by delaying or even stabilizing the progression of white matter lesions,thus stabilizing or even improving the cognitive impairment of patients.With the extension of the history of hypertension,the higher the score of the modified Scheltens scale,the lower the scores of MMSE and MoCA,and the more severe the degree of white matter lesions(WML).Craniocerebral MRI can be used as a routine examination for early detection and diagnosis,and the early intervention of Qianyang Yuyin Granules and other traditional Chinese medicine.