Effect Of Moderate Intensity Aerobic Exercise Combined With Resistance Training On Arterial Stiffness And Cardiopulmonary Function In Patients With Stable Coronary Heart Disease

Objective:To investigate the effects of exercise-based cardiac rehabilitation on improving arterial stiffness,cardiopulmonary function and improving blood lipid in middle-aged patients with stable coronary heart disease(SCAD).Meanwhile,to observe the clinical effects of exercise training on patients with different degree of arterial stiffness.Methods:Sixty middle-aged patients with SCAD were enrolled.All of them were diagnosed with CHD by coronary CTA or coronary angiography.According to the degree of arterial stiffness,the patients were divided into two groups with 30 patients in each group.Patients with cfPWV<10m/s was included in the non-arteriosclerosis group.Patients with cfPWV>10m/s was included in the arteriosclerosis group.Patients in both groups received the same treatment,including regular medication and exercise training.The exercise training consisted of aerobic training at anaerobic threshold level and resistance training at medium to high intensity(60%10RM).Patients exercised 3 times a week for 12 weeks.The aerobic training included cycle training or treadmill training.The changes of VO2peax,AT,VO2/HR,MWL,FEV1%,FCV%,FEVi/FVC,MVV,VE/VCO2@AT,VE/VCO2 slope,VE max,LVEF,cfPWV,baPWV,ABI,TC,TG,HDL-C,LDL-C were observed before and after treatment.Results:1.There was no significant difference in general data(P>0.05).2.After treatment,the VO2peak,AT,VO2/HR,MWL,VEmax,LVEF and HDL-C of the two groups were increased(P<0.05),and the VE/VCO2 slope,TC,TG and LDL-C of the two groups were decreased(P<0.05).3.Before treatment,there were significant differences in VO2/HR,MWL and MVV between the two groups(P<0.05),and VO2/HR,MWL and MVV in arteriosclerosis group were lower than those in the non-arteriosclerosis group.There was no significant difference in other indexes between the two groups(P>0.05).4.After treatment,AT and VO2peak in non-arteriosclerosis group were higher than those in arteriosclerosis group(P<0.05).5.The reduction of baPWV in the arteriosclerosis group was greater than that the non-arteriosclerosis group(P<0.01).The decrease of baPWV was correlated with the baseline of baPWV(r=0.567,P=0.000).Conclusion:1.For patients with stable coronary heart disease,exercise-based cardiac rehabilitation therapy may improve arterial stiffness,cardiopulmonary function and blood lipid.2.The decrease of PWV is positively correlated with the baseline.In patients with high baseline PWV,the decrease in PWV was greater.3.The basline cardiopulmonary function of patients with high arterial stiffness may be relatively poor,and the improvement of cardiopulmonary function after exercise training may be lower than that of patients with normal arterial stiffness.