The Characteristics And Influencing Factors Of Fasting Plasma Glucose,blood Lipids,Serum Uric Acid And Atherogenic Index Of Plasma In Patients With Graves Disease

Objectives:(1)To determine whether fasting plasma glucose(FPG),blood lipids,serum uric acid(SUA),estimated glomerular filtration rate(eGFR),and atherogenic index of plasma(AIP)are statistically significant among the Graves disease(GD)group,the healthy control group and different subgroups of GD and the GD patients’characteristics of metabolic disorders.(2)To explore whether thyroid function,thyrotrophin receptor antibody(TRAb)are related to FPG,blood lipids,SUA,eGFR,AIP and the risk factors of FPG,blood lipids,SUA,eGFR,AIP in GD patients.Methods:A case-control study was used to select 48 GD patients who are≥18 years of age,new-onset,untreated as the GD group,and 62 healthy subjects with gender and age matched at the same time as the control group.According to whether GD patients were combined with impaired fasting glucose(IFG),dyslipidemia,hyperuricemia(HUA),estimated glomerular filtration rate(eGFR)and corrected AIP(cAIP)elevation,the GD group was divided into normal FPG GD1 group(n=31),IFG GD2 group(n=17),normal blood lipid GD3 group(n=26),dyslipidemia GD4 group(n=22),normal SUA GD5 group(n=36),HUA GD6 group(n=12),normal eGFR GD7 group(n=34),elevated eGFR GD8 group(n=14),normal cAIP GD9 group(n=19)and cAIP elevated GD10 group(n=29).Retrospective analysis was performed to collect the genders,Age,body mass index(BMI),thyroid function,thyroid autoantibodies,fasting plasma glucose(FPG),triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),SUA,blood urea nitrogen(Bun),Serum creatinine(Scr),eGFR,cAIP of all subjects,and comparing the differences of the above indicators between the groups and analyze the correlation.The risk factors of FPG,blood lipids,SUA,eGFR,cAIP were analyzed by binary logistic regression.Results:(1)Compared with the control group,TRAb,FT3,FT4,TT3,TT4,FPG,TG,SUA,eGFR,cAIP were increased in the GD group(P<0.05),and thyroid stimulating hormone(TSH),TC,HDL-C,LDL-C,Scr were decreased(P<0.05).(2)FPG,TG,SUA,eGFR,and cAIP in the GD group were higher than those in the same-sex control group(P<0.05),and TC,HDL-C,LDL-C,Scr were lower than those in the same-sex control group(P<0.05).HDL-C was higher in the female GD group than in the male group(P<0.05),and the proportion of SUA,Scr,cAIP,combined TG and HDL-C abnormalities and HUA was lower in the female GD group(P<0.05).(3)Comparison between different subgroups of GD:①Compared with the control group,the GD2 group’s patients are older(P<0.05).Compared with the GD1 group,the GD2 group had higher FPG(P<0.05).②Compared with the control group,the GD4 group had a higher TG,age and proportion of males(P<0.05).Compared with the GD3 group,the proportion of males,TG,cAIP and cAIP increased in the GD4 group were higher(P<0.05),and HDL-C was lower(P<0.05).③Compared with the control group,the age and TG in the GD5 group were higher(P<0.05),and the SUA in the GD6 group was higher(P<0.05).Compared with the GD5 group,the proportion of males,SUA,Bun and the proportions of HUA in the GD6 group were higher(P<0.05).④Compared with the GD7 group,the GD8 group’s patients were younger(P<0.05),and FT3,FT4,TT4,eGFR were higher(P<0.05).⑤ Compared with the control group,age and the proportion of males in the GD10 group were higher(P<0.05).Compared with the GD9 group,TG and cAIP were higher in the GD10 group(P<0.05),and HDL-C was lower in the GD10 group(P<0.05).(4)The univariate correlation analysis of the GD group indicated that TG was positively correlated with Scr(P<0.05),and negatively correlated with HDL-C(P<0.05);TC was positively correlated with HDL-C(P<0.05);HDL-C was positively correlated with females and TC(P<0.05)and negatively correlated with BMI and TG(P<0.05);SUA was positively correlated with Bun,Scr(P<0.05)and negatively correlated with females(P<0.05);cAIP was positively correlated with BMI,TG,Scr(P<0.05)and negatively correlated with females and HDL-C(P<0.05).(5)Binary Logistic regression analysis in the GD group showed that age≥45 years old is a risk factor for IFG(P<0.05).Females are a protective factor for HDL-C reduction(P<0.05),age≥45 years old and FT3≥10.255pg/ml are risk factors(P<0.05).Females are a protective factor for HUA(P<0.05).HDL-C reduction is a risk factor for cAIP increase(P<0.05).Conclusions:(1)GD patients are prone to increase in IFG,TG,SUA and decrease in HDL-C,and the level of cAIP is significantly increased.(2)In GD patients,age≥45 years old is a risk factor for IFG and HDL-C reduction.Females are a risk factor for HUA and HDL-C reduction,FT3≥10.255pg/ml is a risk factor for HDL-C reduction,and HDL-C reduction is a risk factor for cAIP increase.