The Clinical Value Of Preoperative Blood Lipids In Patients With Colorectal Cancer

Objective:To facilitate early clinical identification and intervention and improve the prognosis of patients.The lipid metabolism-related gene CYP2E1 was downloaded from UALCAN-TCGA to explore the effect of its expression on the survival rate of colon adenocarcinoma patients.We retrospectively analyzed the difference between preoperative blood lipid of patients with colorectal cancer and control group,and preliminarily explored the possible clinical vaule of blood lipid in colorectal cancer patients.Methods:From the official website of UALCAN-TCGA(http://ualcan.path.uab.edu/index.html)Download the expression of CYP2E1 gene related to fat metabolism in colon adenocarcinoma,and analyze the prognosis of patients with colon adenocarcinoma by its expression level;select the clinical data of 49 patients with colon cancer in Department of gastrointestinal and hernia surgery,the First Affiliated Hospital of Kunming Medical University from November 2020 to February 2021,A total of 40 patients with rectal cancer and 40 age-matched healthy people in the physical examination center were included in this study.The possible clinical significance of preoperative blood lipids in patients with colorectal cancer was retrospectively analyzed.Spss21.0 statistical software was used for all data analysis.T test was used for measurement data between two groups in accordance with normal distribution,one-way ANOVA was used for measurement data among three groups,and mean±standard deviation was used for test;rank sum test was used for measurement data of non normal distribution;chi square test was used for count data,and chi square test was used for comparison between groups;chi square test or Spearman test was used for correlation analysis Multiple logistic regression was used to explore the influencing factors of TNM staging,P<0.05Results:The expression of CYP2E1 in colon adenocarcinoma was higher than that in normal tissues.The survival rate of patients with high expression of CYP2E1 was significantly lower than that of patients with low expression of CYP2E1,and the difference was statistically significant(P<0.0001).The above conclusions can also be obtained when the expression of CYP2E1 and BMI,sex and race act at the same time.There were significant differences in body weight and BMI among the three groups of colon cancer,rectal cancer and control group(P<0.001),and there were significant differences in TC,TG,HDL-C and LDL-C data among colon cancer,rectal cancer and control group(P<0.05).The correlation analysis between HDL-C before CRC and pathological TNM stage after CRC showed that the difference was statistically significant(r=-0.586,P=0.001).There may be a correlation between HDL-C before CRC and pathological TNM stage after CRC,P<0.05,and parallel line test P<0.05.Conclusions:1.The fat metabolism-related gene CYP2E1 has an impact on the survival rate of patients with colon adenocarcinoma.Early gene detection and early intervention may be helpful to the prognosis and survival of the patients;2.Although there are significant differences in preoperative blood lipids between the three groups of patients,the molecules of the differences.The reason is worth to explore;3.the correlation analysis shows that the high-density cholesterol lipoprotein and tumor staging are moderately related,but the multiple logistic regression suggests that the results are unstable.