Effect Of Gender Differences And BMI On The Efficacy Of Continuous Positive Airway Pressure In Patients With Obstructive Sleep Apnea-hypopnea Syndrome

Objective:To explore the influence of Body Mass Index（BMI）on the efficacy of patients with obstructive Sleep Apnea Hypopnea Syndrome（OSAHS）and possible gender difference.Method:Retrospective evaluations were performed for 912 consecutive patients at Yan’an University Affiliated Hospital and the medical sleep center,West china Hospital,Sichuan University from May 2013 to October 2019.They were all diagnosed with OSAHS and underwent overnight CPAP titration.Atotal of 912 OSAHS patients were selected,including 828 men（90.78%）and 84 women（9.22%）.Their mean age and BMI were（44.6±10.8）years and（26.8±4.6）kg/m²respectively.The sleep structure,hypoxia and sleep respiratory events were compared between baseline and after CPAP titration.The correspondence was analysed by BMI and gender differences.Results:Obese group（BMI≥28）need more CPAP pressure than non-obese group（BMI<28）in the male【（11.13±1.86）vs（10.28±1.68）cm H₂O】.BMI positively correlated with CPAP pressure and the improvement of apnea hypopnea index（AHI）and night hypoxia（r=0.159、0.139 all P<0.005）.Howere,these differences were not found in the female.Conclusion:（1）Male OSAHS patients have more adverse habits than female patients,while female patients have more thyroid diseases and arrhythmias.CPAP treatment can significantly improve the severity of night hypoxia and sleep fragments in OSAHS patients.（2）Compared with female patients,male OSAHS patients showed more obvious improvement in sleep structure after treatment with CPAP.（3）BMI has a greater impact on the severity of the disease and the efficacy of CPAP treatment in male OSAHS patients than in female patients.The higher the BMI in male patients,the higher the CPAP pressure value required.BMI had no significant effect on the condition of female OSAHS patients and the treatment stress of CPAP.（4）In male OSAHS patients,the greater the BMI,the more obvious the improvement of sleep breathing related parameters after CPAP treatment.