Retrospective Analysis Of Clinical Features And Prognosis Between Metaplastic Breast Cancer And Triple Negative Breast Cancer

Objective: Metaplastic breast cancer(MBC)is a very rare type of breast cancer.Most of its molecular typing is triple negative and has strong invasiveness.In this study,the clinical features,pathological features and prognosis of metaplastic breast cancer and triple negative breast cancer were compared to explore the research progress of MBC and the effect of metaplastic components on prognosis.Try to find the risk factors affecting the prognosis of MBC,explore the practical significance behind the phenomenon,and improve the understanding of the disease.To explore its clinical significance,we hope to provide necessary reference for the future diagnosis and treatment of patients.It enables clinicians and researchers to better understand the morphology,prognosis,molecular changes and potential treatment options of this rare breast tumor.Thus we can develop a more appropriate clinical treatment plan through individualized risk assessment.Methods: The clinicopathological data of 17 patients with metaplastic breast cancer and59 patients with triple negative breast cancer treated in the first affiliated Hospital of Bengbu Medical College from January 2010 to January 2018 were analyzed retrospectively.The expressions of molecular markers ER,PR,HER-2,Ki-67 and p53 in two kinds of breast cancer patients were analyzed retrospectively,and the differences of clinicopathological,biological characteristics and prognosis between the two groups were explored by combining age,tumor length,lymph node status,postoperative treatment plan and operation mode.Results:1.Comparison between groups:There was no significant difference in histological grade,TNM stage,mode of operation,postoperative treatment and the expression of ER,PR,HER-2,Ki-67 and CK5/6 between MBC and TNBC groups.There were significant differences in the expression of p53 protein,age,lymph node status and tumor diameter between the two groups(P < 0.05).2.Bariate Logistic regression analysis showed that tumor size ≥T2 compared with TNBC was a risk factor for patients with MBC(P=0.029,OR=4.456,95%CI 1.167-17.014).Compared with TNBC patients,age ≥50 was a risk factor for MBC patients(P=0.002,OR=9.616,95%CI2.218-41.683).3.Kaplan-Meier analysis showed that tumor length and diameter,lymph node status,expression of P53 and CK5/6 were risk factors affecting postoperative RFS(P < 0.05).The3-year overall survival rate of MBC and TNBC was 69.5% and 86.3% respectively.Conclusion: 1.There are differences in clinical characteristics and molecular expression between MBC and TNBC,which suggest that MBC has worse biological behavior.2.The average age of MBC patients was older than that of TNBC patients,and the tumor size of MBC patients was larger than that of TNBC patients.3.The prognosis of MBC is relatively worse than that of TNBC.