A Study On The Correlation Between Presbyvestibulopathy And Total MRI Load Of Cerebral Small Vessels Disease

Objective:To explore the correlation between presbyvestibulopathy(PVP)and the total MRI load of cerebral small vessel disease,and understand the relationship between cerebral senile vestibular disease and small vessel disease(Cerebral small vessel disease,CSVD),Grasp the indications of head imaging examination of PVP population,and to explain the imaging performance reasonably,in order to make accurate diagnosis and rehabilitation treatment for elderly patients with vestibular symptoms such as dizziness and imbalance.Methods: Collect 50 cases of PVP patients who were admitted into the group according to the inclusion and exclusion criteria as the case group,at the same time collect 50 volunteers matched(age,gender,risk factors)as a control group and included in the study.The case group recorded detailed medical history and clinical manifestations.Both groups underwent multimodal cranial MRI(conventional T1 WI,T2WI,FLAIR,DWI,and SWI)head examination,and then the white matter hyperintensity(WMH),lacunar hyperintensity(WMH)on the MRI of each subject included in this study Cerebral infarction(LI),microhemorrhages(CMBs)and perivascular space enlargement(EPVS)were evaluated by imaging,and the total imaging load scale of cerebral small vessel disease was used for scoring and grading.Compare the difference between the four imaging manifestations of CSVD and the total MRI load score between the case group and the control group,and understand the relationship between CSVD and PVP.Results:(1)Compared with the clinical data of PVP patients and the control group,34 cases(68%)in the case group of hypertension,23(46%)in the control group,P<0.05,statistically significant;Other clinical data are not statistically significant;(2)The proportion of PVP patients with severe WMH(DWMH score ≥ 2 points and/or PVWMH score 3 points in the Fazekas scale)accounted for 58.0%,and 36.0% in the control group.The P value of the comparison between the two groups was 0.028,P<0.05,which was statistically significant.The proportion of EPVS on imaging in PVP patients was 66.0%,and that of the control group was 44.0%.The P value of the two groups was 0.027 for statistical comparison,P<0.05,which was statistically significant;while for LI and CMBs,P>0.05,No statistical significance;(3)Compared with the total load score of CSVD imaging,the PVP group accounted for 6% of 0 points,1 was 20%,2was 38%,3 was 26%,and 4 was 10%.In the control group,the proportion of 0 points was 24%,1 was 38%,2 was 24%,3 was 10%,and 4 was 4%.The comparison between the two groups was P<0.05,which was statistically significant.Logistic regression analysis found that the total MRI load score of cerebral small vessel disease is an independent risk factor that affects the occurrence of PVP.Conclusions:(1)The imaging manifestations of PVP patients are mainly white matter hyperintensity and perivascular space enlargement.Hypertension is related to the occurrence of PVP.(2)There is a correlation between MRI total load score and senile vestibular disease,and CSVD image total load score is an independent risk factor for PVP.(3)PVP patients are all elderly people over 60 years old,and their head imaging performance,especially the performance on MRI,can be evaluated by the total load of MRI.