The Research On PSCI And Prognosis Of AIS When MSOAR In The Range Of 0～2 Points

Objective:This study is aimed to research PSCI and the prognosis of AIS in patients with mSOAR in the range of 0～2 points.Method:AIS patients with mSOAR in the range of 0～2 points,admitted to Neurology Department,Affiliated Hospital of Qinghai University from November to December 2019 and April to May 2020 was selected.And they were divided into three groups according to their mSOAR score.General information and laboratory examination results were obtained with the informed consent of patients and their families.The overall cognitive function(MMSE scale)and neurological function(mRS scale)of patients were evaluated within 7 days after AIS onset.Telephone follow-up was conducted in the 3rd and 6th months after AIS onset to re-evaluate global cognitive function(telephone version-MMSE scale)and neurological function recovery(mRS scale).After converting t-MMSE score to MMSE score,PSCI and poor prognosis(mRS≥2 points)were determined.The statistical analysis was done by SPSS 24.0.Firstly,the differences in MMSE and mRS score between three groups were analyzed,and the time trends of MMSE and mRS score were discussed.The incidence of outcome events(PSCI and poor prognosis)of three groups in the 6th month was compared.Then,the factors affecting PSCI and poor prognosis were studied.Finally,mSOAR,NIHSS and mSOAR+NIHSS scales were compared to predict the poor prognosis within 6 months.Graphpad Prism 8.0 was used to drawing graphs.Results:1.There were significant differences in MMSE score between different groups and time,and there was an interactive effect of group and time.In acute phase,the MMSE score of group B was lower than group A.In the 3rd and 6th month,the MMSE score of group B and C were significantly lower than group A.And in acute phase,the 3rd and 6th month,the MMSE score of group A did not change with time,but the MMSE score of group B and C decreased sequentially.2.There were significant differences in mRS score in different groups and time,and there was no interaction.In group A,B and C,the mRS score increased in turn,and the neurological function deteriorated in turn.In acute phase,the 3rd and 6th month,the mRS score decreased successively,and the neurological function gradually recovered.3.In the 6th month,the incidence of PSCI in group A was significantly lower than group B and C,and the incidence of poor prognosis in group A and B was significantly lower than group C.4.Age,gender and education level were the influencing factors of PSCI,and the risk of PSCI was increased in elderly,women,and patients with lower education.5.The higher mS OAR and NIHSS score,the older age at onset,were acociated with the higher risk of poor prognosis(mRS≥2 points).6.mSOAR,NIHSS and mSOAR+NIHSS score were good predictors of poor prognosis in the 6th month,and the ROC AUC of mSOAR+NIHSS score is bigger than mSOAR.Conclusions:1.In the 6th month,the incidence of PSCI in patients with 0 point are lower than 1 and 2 points.The incidence of poor prognosis in patients with 0 and 1 point are lower than 2 points.4.The risk factors for PSCI are getting older,women and low education level.5.The increase of mSOAR and NIHSS score and the age of onset are risk factors for poor prognosis.6.mSOAR,NIHSS,mSOAR+NIHSS score all are good tools for predicting poor prognosis,and the ROC AUC of mSOAR+NIHSS score is bigger than mSOAR.