| Objective: To investigate the impact of baseline high-density lipoprotein cholesterol(HDL-C)level on early vascular healing of drug-eluting stent(DES)in patients with arteriosclerotic cardiovascular disease(ASCVD),using optical coherence tomography(OCT)at 1 and 2 months after stenting.Methods: This retrospective study was based on analysis of the PIONEER-II OCT trial(Clinical Trials.gov Identifier: NCT02747329).Regardless of DES type,we grouped patients at high bleeding risk in each cohort based on baseline HDL-C levels(high level≥1.0mmol/L;low level<1.0mmol/L).Cohort-1 underwent OCT imaging at1 month after percutaneous coronary intervention(PCI)(high HDL-C group: 16 patients with 17 lesions;low HDL-C group: 15 patients with 18 lesions);cohort-2underwent OCT imaging at 2 months after PCI(high HDL-C group: 25 patients with28 lesions;low HDL-C group: 17 patients with 19 lesions).Results: At 1-month follow-up,the strut coverage in the high HDL-C group was significantly higher than in the low HDL-C group(84.53 ± 12.51% vs.72.97 ±15.52%,P = 0.021).At 2-month follow-up,the strut coverage was not significantly different between the high and low HDL-C groups(74.47 ± 18.62% vs.79.37 ±22.32%,P = 0.42).Healing scores showed better healing in the high HDL-C group than in the low HDL-C group at 1-month follow-up(31.13 ± 25.81 vs.54.79 ± 30.69,respectively;P = 0.019),whereas there was comparable healing between the groups at 2-month follow-up(51.23 ± 37.44 for high HDL-C group vs.42.11 ± 45.87 for low HDL-C group;P = 0.46).Conclusions: The results of our analysis showed that patients with higher baseline HDL-C levels(≥1.0mmol/L)had a greater vascular healing than patients with lower baseline HDL-C levels(<1.0mmol/L)at 1 month following DES implantation,but the difference in vascular healing became less evident at 2 months.This suggests that higher HDL-C enhances early neointimal coverage in the vascular healing process following DES implantation. |
PDF Full Text Request